Involvement of nucleotide diphosphate kinase 2 in the reopening of the sensitive period of filial imprinting of domestic chicks (Gallus gallus domesticus)

Shinji Yamaguchi, Naoya Aoki, Akihiko Takehara, Masaru Mori, Akio Kanai, Toshiya Matsushima, Koichi J. Homma

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Filial imprinting is a behavior characterized by the sensitive or critical period restricted to the first few days after hatching. Once the sensitive period is closed, it is widely believed that chicks can never be imprinted under natural conditions. Previously, we showed that the exogenous injection of T3 reopened the sensitive period which was already closed. That study suggested that T3 functioned by way of a rapid non-genomic action; however, the molecular mechanism of how T3 reopens the sensitive period remains unknown. Here, we show that the phosphorylation level of nucleotide diphosphate kinase 2 (NDPK2) was upregulated following T3 injection. Pharmacological deprivation of the kinase activity of NDPK hampered the molecular process prerequisite for the reopening of the sensitive period of filial imprinting. Moreover, it is shown that the kinase activity of NDPK2 participates in the priming process by T3 signaling which endows the potential for learning. Our data indicate that NDPK2 plays a crucial role downstream of T3 action and that its phosphorylation is involved in the non-genomic signaling during imprinting.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalNeuroscience Letters
Volume612
DOIs
Publication statusPublished - 2016 Jan 26

Fingerprint

Diphosphates
Chickens
Phosphotransferases
Nucleotides
Phosphorylation
Injections
Imprinting (Psychology)
Learning
Pharmacology

Keywords

  • Filial imprinting
  • Learning
  • NDPK2
  • Non-genomic signaling
  • Sensitive period
  • Thyroid hormone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Involvement of nucleotide diphosphate kinase 2 in the reopening of the sensitive period of filial imprinting of domestic chicks (Gallus gallus domesticus). / Yamaguchi, Shinji; Aoki, Naoya; Takehara, Akihiko; Mori, Masaru; Kanai, Akio; Matsushima, Toshiya; Homma, Koichi J.

In: Neuroscience Letters, Vol. 612, 26.01.2016, p. 32-37.

Research output: Contribution to journalArticle

Yamaguchi, Shinji ; Aoki, Naoya ; Takehara, Akihiko ; Mori, Masaru ; Kanai, Akio ; Matsushima, Toshiya ; Homma, Koichi J. / Involvement of nucleotide diphosphate kinase 2 in the reopening of the sensitive period of filial imprinting of domestic chicks (Gallus gallus domesticus). In: Neuroscience Letters. 2016 ; Vol. 612. pp. 32-37.
@article{2092c6ec75754e04983b74a8eafe18f3,
title = "Involvement of nucleotide diphosphate kinase 2 in the reopening of the sensitive period of filial imprinting of domestic chicks (Gallus gallus domesticus)",
abstract = "Filial imprinting is a behavior characterized by the sensitive or critical period restricted to the first few days after hatching. Once the sensitive period is closed, it is widely believed that chicks can never be imprinted under natural conditions. Previously, we showed that the exogenous injection of T3 reopened the sensitive period which was already closed. That study suggested that T3 functioned by way of a rapid non-genomic action; however, the molecular mechanism of how T3 reopens the sensitive period remains unknown. Here, we show that the phosphorylation level of nucleotide diphosphate kinase 2 (NDPK2) was upregulated following T3 injection. Pharmacological deprivation of the kinase activity of NDPK hampered the molecular process prerequisite for the reopening of the sensitive period of filial imprinting. Moreover, it is shown that the kinase activity of NDPK2 participates in the priming process by T3 signaling which endows the potential for learning. Our data indicate that NDPK2 plays a crucial role downstream of T3 action and that its phosphorylation is involved in the non-genomic signaling during imprinting.",
keywords = "Filial imprinting, Learning, NDPK2, Non-genomic signaling, Sensitive period, Thyroid hormone",
author = "Shinji Yamaguchi and Naoya Aoki and Akihiko Takehara and Masaru Mori and Akio Kanai and Toshiya Matsushima and Homma, {Koichi J.}",
year = "2016",
month = "1",
day = "26",
doi = "10.1016/j.neulet.2015.12.004",
language = "English",
volume = "612",
pages = "32--37",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Involvement of nucleotide diphosphate kinase 2 in the reopening of the sensitive period of filial imprinting of domestic chicks (Gallus gallus domesticus)

AU - Yamaguchi, Shinji

AU - Aoki, Naoya

AU - Takehara, Akihiko

AU - Mori, Masaru

AU - Kanai, Akio

AU - Matsushima, Toshiya

AU - Homma, Koichi J.

PY - 2016/1/26

Y1 - 2016/1/26

N2 - Filial imprinting is a behavior characterized by the sensitive or critical period restricted to the first few days after hatching. Once the sensitive period is closed, it is widely believed that chicks can never be imprinted under natural conditions. Previously, we showed that the exogenous injection of T3 reopened the sensitive period which was already closed. That study suggested that T3 functioned by way of a rapid non-genomic action; however, the molecular mechanism of how T3 reopens the sensitive period remains unknown. Here, we show that the phosphorylation level of nucleotide diphosphate kinase 2 (NDPK2) was upregulated following T3 injection. Pharmacological deprivation of the kinase activity of NDPK hampered the molecular process prerequisite for the reopening of the sensitive period of filial imprinting. Moreover, it is shown that the kinase activity of NDPK2 participates in the priming process by T3 signaling which endows the potential for learning. Our data indicate that NDPK2 plays a crucial role downstream of T3 action and that its phosphorylation is involved in the non-genomic signaling during imprinting.

AB - Filial imprinting is a behavior characterized by the sensitive or critical period restricted to the first few days after hatching. Once the sensitive period is closed, it is widely believed that chicks can never be imprinted under natural conditions. Previously, we showed that the exogenous injection of T3 reopened the sensitive period which was already closed. That study suggested that T3 functioned by way of a rapid non-genomic action; however, the molecular mechanism of how T3 reopens the sensitive period remains unknown. Here, we show that the phosphorylation level of nucleotide diphosphate kinase 2 (NDPK2) was upregulated following T3 injection. Pharmacological deprivation of the kinase activity of NDPK hampered the molecular process prerequisite for the reopening of the sensitive period of filial imprinting. Moreover, it is shown that the kinase activity of NDPK2 participates in the priming process by T3 signaling which endows the potential for learning. Our data indicate that NDPK2 plays a crucial role downstream of T3 action and that its phosphorylation is involved in the non-genomic signaling during imprinting.

KW - Filial imprinting

KW - Learning

KW - NDPK2

KW - Non-genomic signaling

KW - Sensitive period

KW - Thyroid hormone

UR - http://www.scopus.com/inward/record.url?scp=84954108618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954108618&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2015.12.004

DO - 10.1016/j.neulet.2015.12.004

M3 - Article

VL - 612

SP - 32

EP - 37

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -