@article{2092c6ec75754e04983b74a8eafe18f3,
title = "Involvement of nucleotide diphosphate kinase 2 in the reopening of the sensitive period of filial imprinting of domestic chicks (Gallus gallus domesticus)",
abstract = "Filial imprinting is a behavior characterized by the sensitive or critical period restricted to the first few days after hatching. Once the sensitive period is closed, it is widely believed that chicks can never be imprinted under natural conditions. Previously, we showed that the exogenous injection of T3 reopened the sensitive period which was already closed. That study suggested that T3 functioned by way of a rapid non-genomic action; however, the molecular mechanism of how T3 reopens the sensitive period remains unknown. Here, we show that the phosphorylation level of nucleotide diphosphate kinase 2 (NDPK2) was upregulated following T3 injection. Pharmacological deprivation of the kinase activity of NDPK hampered the molecular process prerequisite for the reopening of the sensitive period of filial imprinting. Moreover, it is shown that the kinase activity of NDPK2 participates in the priming process by T3 signaling which endows the potential for learning. Our data indicate that NDPK2 plays a crucial role downstream of T3 action and that its phosphorylation is involved in the non-genomic signaling during imprinting.",
keywords = "Filial imprinting, Learning, NDPK2, Non-genomic signaling, Sensitive period, Thyroid hormone",
author = "Shinji Yamaguchi and Naoya Aoki and Akihiko Takehara and Masaru Mori and Akio Kanai and Toshiya Matsushima and Homma, {Koichi J.}",
note = "Funding Information: This work was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (N.A., 24790089 ; S.Y., 24590096 , 15K07945 ; T.M., 25291071 ; K.J.H., 26440182 ); the Grant-in-Aid for Scientific Research on Innovative Areas “Memory dynamism” (26115522) and “Adaptive circuit shift” (15H01449) from the Ministry of Education, Culture, Sports, Science and Technology (K.J.H.); the Naito Foundation (K.J.H.); the Japan Foundation of Applied Enzymology (K.J.H.); NOVARTIS Foundation (Japan) for the Promotion of Science (K.J.H.); the Uehara Memorial Foundation (K.J.H., S.Y.); the Sagawa Foundation for Promotion of Cancer Research (S.Y.); Sumitomo Foundation (S.Y.); Takeda Science Foundation (S.Y.); and the Pharmaceutical Society of Japan Award for Young Scientists (S.Y.). We thank Dr. Kazuhiro Wada for providing the protocol for genomic PCR used for gender identification of the chicks. We thank Takaaki Kitajima for technical assistance. Publisher Copyright: {\textcopyright} 2015 Elsevier Ireland Ltd.",
year = "2016",
month = jan,
day = "26",
doi = "10.1016/j.neulet.2015.12.004",
language = "English",
volume = "612",
pages = "32--37",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
}