Involvement of tyrosine kinase in growth factor-induced phospholipase C activation in NIH3T3 cells

Masaya Imoto, Ikuo Sujikai, Hideaki Ui, Kazuo Umezawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Tyrosine kinase inhibitors such as erbstatin and lavendustin derivative inhibited platelet-derived growth factor (PDGF)- and bombesin-induced inositol phosphate formation and phospholipase C (PLC) activation in quiescent NIH3T3 cells. However, bombesin-induced PLC activation was only partially inhibited by tyrosine kinase inhibitors, whereas PDGF-induced activation was completely. Moreover, although bombesin-induced PLC activation was partially inhibited by pertussis toxin alone, this toxin inhibited almost completely in the presence of tyrosine kinase inhibitors. Thus, tyrosine kinase was suggested to be involved in PDGF- and bombesin-induced PLC activation in a different manner.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume1166
Issue number2-3
DOIs
Publication statusPublished - 1993 Feb 24

Keywords

  • Bombesin
  • G-protein
  • Phospholipase C
  • Platelet-derived growth factor
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

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