Ion-selective electrodes based on natural carboxylic polyether antibiotics

Koji Suzuki, Koji Tohda, Hiroshi Aruga, Misako Matsuzoe, Hidenari Inoue, Tsuneo Shirai

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Abstract

The response characteristics of poly (vinyl chloride) (PVC) matrix membrane ion-selective electrodes based on five natural carboxylic polyether antibiotics, ionomycin, lasalocid, monensin, nigericin, and salinomycin, were examined. These are characterized by a good response to divalent (alkaline-earth-metal) cations such as Ca2+and Ba2+. However, electrodes based on methyl esters, in which the carboxyl groups of the natural carboxylic polyethers are esterified, responded weakly to divaient cations. This indicated that the carboxyl group plays an important role in making a complex with the divalent cation in a lipophilic polymeric electrode membrane, which is significant for the electrode response to the divalent cation. Electrodes based on all the carboxylic polyethers except lasalocid show "bl-Nernstian response" for divalent cations. In order to explain this unusual response, Ion extraction and permeability measurements were carried out with lasalocid and monensin. The general relationship between electrode response and ion extraction or ion-ligand complexation is also discussed on the basis of the results obtained with lasalocid and monensin.

Original languageEnglish
Pages (from-to)1714-1721
Number of pages8
JournalAnalytical Chemistry
Volume60
Issue number17
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Analytical Chemistry

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    Suzuki, K., Tohda, K., Aruga, H., Matsuzoe, M., Inoue, H., & Shirai, T. (1988). Ion-selective electrodes based on natural carboxylic polyether antibiotics. Analytical Chemistry, 60(17), 1714-1721.