Ion sensing film optodes: disposable ion sensing probes for the determination of Na+, K+, Ca2+ and Cl- concentrations in serum

Hisamoto Hideaki Hisamoto, Miyashita Nami Miyashita, Watanabe Kazuhiko Watanabe, Nakagawa Eriko Nakagawa, Yamamoto Noriko Yamamoto, Suzuki Koji Suzuki

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


Highly selective ion sensing film optodes for the determination of four kinds of ions (Na+, K+, Ca2+, Cl-) were prepared with plasticized PVC membranes containing the respective ionophores and a newly prepared lipophilic anionic dye. The principle of the optical response of these sensing films is based on ion-pair extraction of the ion-ionophore complex and a deprotonated or protonated lipophilic anionic dye. These film optodes are for disposable use and can detect ions by simply immersing them into a glass vessel which is filled with the samples solution and determining the ion by measuring the absorbance change at the respective maximum absorption wavelength of the lipophilic anionic dyes in the visible region. The theoretical response of these films was also discussed based on the ion-extraction model. The ion selectivity of these films was sufficient for the determination of Na+, K+, Ca2+ and Cl- in diluted serum samples, and satisfactory results were obtained in serum analysis.

Original languageEnglish
Pages (from-to)378-385
Number of pages8
JournalSensors and Actuators: B. Chemical
Issue number1-3
Publication statusPublished - 1995 Oct


  • Calcium
  • Chlorine
  • Ion sensing film optodes
  • Potassium
  • Serum
  • Sodium

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry


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