Ion-sensitive field effect transistor as a monovalent cation detector for ion chromatography and its application to the measurement of Na+ and K+ concentrations in serum

Kazuhiko Watanabe, Koji Tohda, Hitoshi Sugimoto, Fumihiko Eitoku, Hidenari Inoue, Koji Suzuki, Shigeru Nakamura

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

An ion-sensitive field effect transistor, which is a small potentiometric ion-sensing probe, was applied as a detector in the ion chromatography of alkali-metal cations. The cation-sensing transistor was prepared by coating the gate part of the probe to form a poly(vinyl chloride) matrix membrane containing tetranactin, which enables detection of alkali-metal ions such as Na+, K+, Rb+, and Cs+. To be able to analyse amounts less than 1 μl and make full use of the small ion-sensing probe, we constructed a miniature cation-exchange separation column (support 10 μm polystyrene) with a PTFE tube (20 mm × 1.5 mm I.D. × 2.1 mm O.D.). As an application of the system, Na+ and K+ concentrations in serum were determined. The analytical results for these two cations were good agreement with those obtained by flame photometry.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalJournal of Chromatography B: Biomedical Sciences and Applications
Volume566
Issue number1
DOIs
Publication statusPublished - 1991 May 3

ASJC Scopus subject areas

  • Chemistry(all)

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