IPS cell technologies: Significance and applications to CNS regeneration and disease

Hideyuki Okano, Shinya Yamanaka

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

In 2006, we demonstrated that mature somatic cells can be reprogrammed to a pluripotent state by gene transfer, generating induced pluripotent stem (iPS) cells. Since that time, there has been an enormous increase in interest regarding the application of iPS cell technologies to medical science, in particular for regenerative medicine and human disease modeling. In this review article, we outline the current status of applications of iPS technology to cell therapies (particularly for spinal cord injury), as well as neurological disease-specific iPS cell research (particularly for Parkinson's disease and Alzheimer's disease). Finally, future directions of iPS cell research are discussed including a) development of an accurate assay system for disease-associated phenotypes, b) demonstration of causative relationships between genotypes and phenotypes by genome editing, c) application to sporadic and common diseases, and d) application to preemptive medicine.

Original languageEnglish
Article number22
JournalMolecular Brain
Volume7
Issue number1
DOIs
Publication statusPublished - 2014 Mar 31

Fingerprint

Induced Pluripotent Stem Cells
Central Nervous System Diseases
Regeneration
Technology
Stem Cell Research
Phenotype
Regenerative Medicine
Cell- and Tissue-Based Therapy
Spinal Cord Injuries
Parkinson Disease
Alzheimer Disease
Genotype
Medicine
Genes

Keywords

  • Alzheimer's disease
  • Cell transplantation
  • Induced pluripotent stem cell
  • Modeling human diseases
  • Parkinson's disease
  • Spinal cord injury

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology

Cite this

IPS cell technologies : Significance and applications to CNS regeneration and disease. / Okano, Hideyuki; Yamanaka, Shinya.

In: Molecular Brain, Vol. 7, No. 1, 22, 31.03.2014.

Research output: Contribution to journalArticle

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