IRBIT: A regulator of ion channels and ion transporters

Hideaki Ando, Katsuhiro Kawaai, Katsuhiko Mikoshiba

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


IRBIT (also called AHCYL1) was originally identified as a binding protein of the intracellular Ca2+ channel inositol 1,4,5-trisphosphate (IP3) receptor and functions as an inhibitory regulator of this receptor. Unexpectedly, many functions have subsequently been identified for IRBIT including the activation of multiple ion channels and ion transporters, such as the Na+/HCO3- co-transporter NBCe1-B, the Na+/H+ exchanger NHE3, the Cl- channel cystic fibrosis transmembrane conductance regulator (CFTR), and the Cl-/HCO3- exchanger Slc26a6. The characteristic serine-rich region in IRBIT plays a critical role in the functions of this protein. In this review, we describe the evolution, domain structure, expression pattern, and physiological roles of IRBIT and discuss the potential molecular mechanisms underlying the coordinated regulation of these diverse ion channels/transporters through IRBIT. This article is part of a Special Issue entitled: Calcium signaling in health and disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau.

Original languageEnglish
Pages (from-to)2195-2204
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Issue number10
Publication statusPublished - 2014 Oct
Externally publishedYes


  • IP3 receptor

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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