IRFs: Master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

Kenya Honda, Tadatsugu Taniguchi

Research output: Contribution to journalReview article

1060 Citations (Scopus)

Abstract

The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown to have functionally diverse roles in the regulation of the immune system. Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll-like receptors and other pattern-recognition receptors.

Original languageEnglish
Pages (from-to)644-658
Number of pages15
JournalNature Reviews Immunology
Volume6
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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