Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides

Yoshito Takahashi, Risa Yoshii, Takaaki Sato, Noritaka Chida

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the Mannich reaction, allylation, and [3 + 2]-cycloaddition. The method shows high chemoselectivity in the presence of other functional groups such as methyl ester.

Original languageEnglish
Pages (from-to)5705-5708
Number of pages4
JournalOrganic Letters
Issue number18
Publication statusPublished - 2018 Sept 21

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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