Abstract
An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the Mannich reaction, allylation, and [3 + 2]-cycloaddition. The method shows high chemoselectivity in the presence of other functional groups such as methyl ester.
Original language | English |
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Pages (from-to) | 5705-5708 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 20 |
Issue number | 18 |
DOIs | |
Publication status | Published - 2018 Sep 21 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry