Abstract
An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the Mannich reaction, allylation, and [3 + 2]-cycloaddition. The method shows high chemoselectivity in the presence of other functional groups such as methyl ester.
| Original language | English |
|---|---|
| Pages (from-to) | 5705-5708 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 20 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 2018 Sep 21 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Cite this
Takahashi, Y., Yoshii, R., Satou, T., & Chida, N. (2018). Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides. Organic Letters, 20(18), 5705-5708. https://doi.org/10.1021/acs.orglett.8b02421