Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging

Michiaki Kumagai, Yutaka Imai, Teisaku Nakamura, Yuichi Yamasaki, Masaki Sekino, Shoogo Ueno, Kenjiro Hanaoka, Kazuya Kikuchi, Tetsuo Nagano, Eiji Kaneko, Kentaro Shimokado, Kazunori Kataoka

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)

Abstract

PEG-coated β-FeOOH nanoparticles were prepared through electrostatic complex formation of iron oxide nanoparticles with poly(ethylene glycol)-poly(aspartic acid) block copolymer [PEG-P(Asp)] in distilled water. By dynamic light scattering (DLS) measurement, the nanopaticle size was determined to be 70 nm with narrow distribution. The FT-IR and zeta potential experimental results proved that PEG-PAsp molecules bound to the surface of the iron oxide nanoparticles via the coordination between the carboxylic acid residues in the PAsp segment of the block copolymer and the surface Fe of the β-FeOOH nanoparticles. The PEG-coated nanoparticles revealed excellent solubility and stability in aqueous solution as well as in physiological saline. In vivo MRI experiments on tumor-bearing mice demonstrated that the PEG-coated nanoparticles prepared by the current approach achieved an appreciable accumulation into solid tumor, suggesting their potential utility as tumor-selective MRI contrast agents.

Original languageEnglish
Pages (from-to)174-181
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume56
Issue number1-2
DOIs
Publication statusPublished - 2007 Apr 15
Externally publishedYes

Keywords

  • Block copolymer
  • Contrast agent
  • FT-IR
  • Magnetic resonance imaging
  • Poly(ethylene glycol)
  • Tumor
  • Zeta potential
  • β-FeOOH

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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