Is central dogma a global property of cellular information flow?

Vincent Piras, Masaru Tomita, Kumar Selvarajoo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The central dogma of molecular biology has come under scrutiny in recent years. Here, we reviewed high-throughput mRNA and protein expression data of Escherichia coli, Saccharomyces cerevisiae, and several mammalian cells. At both single cell and population scales, the statistical comparisons between the entire transcriptomes and proteomes show clear correlation structures. In contrast, the pair-wise correlations of single transcripts to proteins show nullity. These data suggest that the organizing structure guiding cellular processes is observed at omics-wide scale, and not at single molecule level. The central dogma, thus, globally emerges as an average integrated flow of cellular information.

Original languageEnglish
Article numberArticle 439
JournalFrontiers in Physiology
Volume3 NOV
DOIs
Publication statusPublished - 2012

Fingerprint

Cellular Structures
Proteome
Transcriptome
Saccharomyces cerevisiae
Molecular Biology
Proteins
Escherichia coli
Messenger RNA
Population

Keywords

  • Biological noise
  • Central dogma
  • Correlation analysis
  • Emergent behavior
  • Gene expression

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Is central dogma a global property of cellular information flow? / Piras, Vincent; Tomita, Masaru; Selvarajoo, Kumar.

In: Frontiers in Physiology, Vol. 3 NOV, Article 439, 2012.

Research output: Contribution to journalArticle

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