Is Local Production of Autoantibodies in Skin Lesions Relevant in Pemphigus?

Hisashi Nomura, Masayuki Amagai

Research output: Contribution to journalComment/debate

Abstract

Pemphigus is an autoimmune bullous disease characterized by IgG production against desmogleins. The major sites of autoantibody production are thought to be lymph nodes, spleen, and bone marrow. Previously, it has been suggested that autoreactive B cells might exist in the skin lesions in pemphigus and produce autoantibodies. In their report, Zhou et al. expanded their previous studies and reported that ectopic lymphoid-like structures were found in pemphigus skin lesions, wherein B-cell differentiation and lesional B-cell expansion might progress. This finding provides novel insights into B-cell biology in pemphigus.

Original languageEnglish
Pages (from-to)275-276
Number of pages2
JournalJournal of Investigative Dermatology
Volume140
Issue number2
DOIs
Publication statusPublished - 2020 Feb

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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