Is oral mucositis occurring during chemotherapy for esophageal cancer patients correctly judged? EPOC observational cohort study

Yoshihiro Tanaka, Takao Ueno, Naoya Yoshida, Yasunori Akutsu, Hiroya Takeuchi, Hideo Baba, Hisahiro Matsubara, Yuko Kitagawa, Kazuhiro Yoshida

Research output: Contribution to journalArticle

Abstract

Background/Aim: Oral mucositis (OM) is one of the frequent adverse events experienced by patients receiving chemotherapy. Most diagnoses of OM are based on complaints from patients. The aim of this study was to develop a tool to diagnose OM accurately. Materials and Methods: A central review system (CRS) was created to allow judgment when the patient background is completely unknown. The primary endpoint was the rate of grade 2 or higher OM, and the secondary endpoint was the difference in grade between each institution’s clinician judgement and that of the CRS. Results: In total, 53 patients were registered from four institutions. CRS successfully detected grade 2 or higher OM in 16 (30.2%) of the 53 patients. The detection rate of all grades of OM was 41.5% (22 of 53 patients) by each institution’s clinician judgement and 84.9% (45 of 53 patients) by CRS judgement (p<0.0001). Conclusion: OM during chemotherapy may be underestimated.

Original languageEnglish
Pages (from-to)4441-4448
Number of pages8
JournalAnticancer research
Volume39
Issue number8
DOIs
Publication statusPublished - 2019

Keywords

  • Central review system
  • Chemotherapy
  • Esophageal carcinoma
  • Oral mucositis
  • Underestimation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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