Is type 2 diabetes mellitus an inverse risk factor for the development of rheumatoid arthritis?

Jun Inamo, Yuta Kochi, Tsutomu Takeuchi

Research output: Contribution to journalArticlepeer-review

Abstract

Type 2 diabetes mellitus (T2DM) and rheumatoid arthritis (RA) are both chronic diseases. Although the link between metabolic abnormalities and dysregulated inflammation has received much attention, it is not known whether T2DM can be a risk for the development of RA. Also, observational studies have the disadvantage that the possibility of confounding factors, such as environmental factors, cannot be ruled out. Therefore, the current study performed the mendelian randomization (MR) analysis using recent large-scale genome-wide association studies datasets of T2DM and RA separately European and Asian ancestries. As a result, T2DM had an inverse causal effect on the risk of RA. This study proposed a novel hypothesis that a protective effect of T2DM for the risk of RA.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalJournal of Human Genetics
Volume66
Issue number2
DOIs
Publication statusPublished - 2021 Feb

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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