Ischemic bowel necrosis induced by endothelin-1: An experimental model in rats

S. Miura, I. Kurose, D. Fukumura, M. Suematsu, E. Sekizuka, H. Tashiro, H. Serizawa, H. Asako, M. Tsuchiya

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Local intra-arterial administration of endothelin-1 induced small intestinal mucosal damage in rats in a dose-dependent manner. A remarkable decrease in mucosal blood flow (15% of control values) was observed by a laser Doppler flowmetry 10 min after injection of endothelin-1 (1 nmol/kg). Endothelin-1 at this dose induced significant hemorrhagic and necrotic lesions in the small intestinal mucosa 30 min after the injection. Decreased mucosal blood flow was attenuated to some extent by the pretreatment with platelet-activating factor (PAF) inhibitor, CV-6209, superoxide dismutase plus catalase or the calcium antagonist, nicorandil. All these inhibitors significantly prevented the endothelin-1-induced ischemic necrotic damage in the small intestine. These results suggest a potential role of endothelin- 1 in the pathogenesis of ischemic bowel diseases in clinical situations and also the possibility that PAF and oxygen-derived free radicals may be involved as secondary mediators in endothelin-induced intestinal tissue damage.

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalDigestion
Volume48
Issue number3
Publication statusPublished - 1991

Fingerprint

Endothelin-1
Theoretical Models
Necrosis
Platelet Activating Factor
Nicorandil
Laser-Doppler Flowmetry
Injections
Endothelins
Intestinal Mucosa
Catalase
Superoxide Dismutase
Small Intestine
Free Radicals
Oxygen
Calcium

Keywords

  • endothelin-1
  • ischemic bowel necrosis
  • mucosal blood flow
  • oxygen-derived free radicals
  • platelet-activating factor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Miura, S., Kurose, I., Fukumura, D., Suematsu, M., Sekizuka, E., Tashiro, H., ... Tsuchiya, M. (1991). Ischemic bowel necrosis induced by endothelin-1: An experimental model in rats. Digestion, 48(3), 163-172.

Ischemic bowel necrosis induced by endothelin-1 : An experimental model in rats. / Miura, S.; Kurose, I.; Fukumura, D.; Suematsu, M.; Sekizuka, E.; Tashiro, H.; Serizawa, H.; Asako, H.; Tsuchiya, M.

In: Digestion, Vol. 48, No. 3, 1991, p. 163-172.

Research output: Contribution to journalArticle

Miura, S, Kurose, I, Fukumura, D, Suematsu, M, Sekizuka, E, Tashiro, H, Serizawa, H, Asako, H & Tsuchiya, M 1991, 'Ischemic bowel necrosis induced by endothelin-1: An experimental model in rats', Digestion, vol. 48, no. 3, pp. 163-172.
Miura S, Kurose I, Fukumura D, Suematsu M, Sekizuka E, Tashiro H et al. Ischemic bowel necrosis induced by endothelin-1: An experimental model in rats. Digestion. 1991;48(3):163-172.
Miura, S. ; Kurose, I. ; Fukumura, D. ; Suematsu, M. ; Sekizuka, E. ; Tashiro, H. ; Serizawa, H. ; Asako, H. ; Tsuchiya, M. / Ischemic bowel necrosis induced by endothelin-1 : An experimental model in rats. In: Digestion. 1991 ; Vol. 48, No. 3. pp. 163-172.
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