Islet Cell Tumor in von Hippel-Lindau Disease

Nobumasa Mizlno, Satoru Naruse, Motoji Kitagawa, Hiroshi Ishiguro, Yasuyuki Nakak, Hideaki Ihda, Naohiko Iizuka, Osamu Ito, Yasunaga Seki, Shigeru B.H. Ko, Toshiyuki Yoshikawa, Tetsuo Hayakawa, Tsuyoshi Sano, Junichi Kamiya, Yuji Nimura, Tetsuro Nagasaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We describe a 42-year-old man with von Hippel-Lindau disease and islet cell tumor of the pancreas. He had retinal and cerebellar hemangioblastomas. His sister had pheochromocytoma. A pancreatic tumor was detected by ultrasonography at his periodical medical checkup. Contrast enhanced computed tomography and abdominal angiography revealed a hypervascular tumor in the pancreatic head. Histological examination of the resected tumor revealed characteristics of islet cell tumor of the pancreas, which was positive for chromogranin- A, S-100 protein, and pancreatic polypeptide, but was negative for insulin, gastrin, glucagon, somatostatin, vasoactive intestinal peptide, serotonin, and adrenocorticotropic hormone.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalInternal Medicine
Volume37
Issue number3
Publication statusPublished - 1998 Dec 1

    Fingerprint

Keywords

  • Hemangioblastoma
  • Pancreatic polypeptide producing tumor

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Mizlno, N., Naruse, S., Kitagawa, M., Ishiguro, H., Nakak, Y., Ihda, H., Iizuka, N., Ito, O., Seki, Y., Ko, S. B. H., Yoshikawa, T., Hayakawa, T., Sano, T., Kamiya, J., Nimura, Y., & Nagasaka, T. (1998). Islet Cell Tumor in von Hippel-Lindau Disease. Internal Medicine, 37(3), 295-299.