Islet number rather than islet size is a major determinant of α- And β-Cell mass in humans

Kinsei Kou, Yoshifumi Saisho, Seiji Sato, Taketo Yamada, Hiroshi Itoh

Research output: Contribution to journalArticle

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Abstract

Objective: The objective of the study was to clarify the relative contribution of islet number and islet size to α- and β-cell mass in humans. Research Design and Methods: We obtained the pancreas at autopsy from 72 Japanese adults with no history of diabetes or pancreatitis (aged 47 ± 12 years, body mass index 24.1 ± 5.0 kg/m2). Pancreatic sections were stained for insulin or glucagon, and fractional ±-cell area (%BCA) and β-cell area (%ACA) were measured. Islet number and islet size as well as ±-cell turnover were also quantified. Glycosylated hemoglobin measured within 1 year prior to death was obtained in 38 individuals. Results: There was considerable interindividual variation in islet density and mean islet size, with a significant negative correlation between the two (r = -0.25, P = .03). There were significant positive correlations between islet density and %BCA or %ACA (r = 0.63, P < .001, and r = 0.41, P = .001), whereas mean islet size correlated with neither of them. Islet density as well as %BCA, but not mean islet size, was negatively correlated with glycosylated hemoglobin (r=-0.37, P = .02, and r = -0.36, P = .03). Conclusion: The present study suggests that islet number rather than islet size is a major determinant of ±- and =-cell mass in humans. Interindividual difference in islet number may contribute to susceptibility to development of glucose intolerance.

Original languageEnglish
Pages (from-to)1733-1740
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number5
DOIs
Publication statusPublished - 2014

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Glycosylated Hemoglobin A
Medical problems
Glucagon
Insulin
Glucose
Glucose Intolerance
Cell Size
Pancreatitis
Pancreas
Autopsy
Body Mass Index
Research Design

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Islet number rather than islet size is a major determinant of α- And β-Cell mass in humans. / Kou, Kinsei; Saisho, Yoshifumi; Sato, Seiji; Yamada, Taketo; Itoh, Hiroshi.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 5, 2014, p. 1733-1740.

Research output: Contribution to journalArticle

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