Isoflavone Intake in Early Pregnancy and Hypospadias in the Japan Environment and Children's Study

The Japan Environment and Children's Study Group

Research output: Contribution to journalArticle

Abstract

Objective: To explore the association between isoflavone intake in early pregnancy (the critical window of masculinisation) and hypospadias. Since oestrogen is likely to contribute to the differentiation of male external genitalia, dietary intake of isoflavone, which has a similar structure to human oestrogen, may be associated with the occurrence of hypospadias. However, there has been little evidence of this association. Materials and Methods: We used data of a nationwide birth cohort study, which recruited women as early in pregnancy as possible throughout Japan between 2011 and 2014. From the response to a self-administered food-frequency questionnaire, the daily intake of genistein (as a representative for isoflavone) was estimated. Information on hypospadias cases that were diagnosed until the first month after birth was obtained from medical records. Odds ratios (ORs) of hypospadias were estimated using a logistic regression model. Results: Among 41,578 mothers, who delivered singleton live male births, the median genistein intake was 15.3 mg/day, and a total of 51 cases of hypospadias were identified. Compared with mothers in the reference group (genistein intake 11th-89th percentiles), those in the low intake group (≤10th percentile) had an elevated risk of their sons having hypospadias (multivariable-adjusted OR = 2.8, 95% confidence interval = 1.4-5.8). Adverse or beneficial effects of genistein on hypospadias were not observed in the high intake group (≥90th percentile) (OR = 0.9, 95% confidence interval = 0.4-2.4). Conclusion: Low maternal intake of isoflavone in early pregnancy was associated with an elevated risk of hypospadias.

Original languageEnglish
JournalUrology
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Hypospadias
Isoflavones
Japan
Pregnancy
Genistein
Odds Ratio
Mothers
Estrogens
Logistic Models
Parturition
Confidence Intervals
Male Genitalia
Live Birth
Nuclear Family
Medical Records
Cohort Studies
Food

ASJC Scopus subject areas

  • Urology

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Isoflavone Intake in Early Pregnancy and Hypospadias in the Japan Environment and Children's Study. / The Japan Environment and Children's Study Group.

In: Urology, 01.01.2018.

Research output: Contribution to journalArticle

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title = "Isoflavone Intake in Early Pregnancy and Hypospadias in the Japan Environment and Children's Study",
abstract = "Objective: To explore the association between isoflavone intake in early pregnancy (the critical window of masculinisation) and hypospadias. Since oestrogen is likely to contribute to the differentiation of male external genitalia, dietary intake of isoflavone, which has a similar structure to human oestrogen, may be associated with the occurrence of hypospadias. However, there has been little evidence of this association. Materials and Methods: We used data of a nationwide birth cohort study, which recruited women as early in pregnancy as possible throughout Japan between 2011 and 2014. From the response to a self-administered food-frequency questionnaire, the daily intake of genistein (as a representative for isoflavone) was estimated. Information on hypospadias cases that were diagnosed until the first month after birth was obtained from medical records. Odds ratios (ORs) of hypospadias were estimated using a logistic regression model. Results: Among 41,578 mothers, who delivered singleton live male births, the median genistein intake was 15.3 mg/day, and a total of 51 cases of hypospadias were identified. Compared with mothers in the reference group (genistein intake 11th-89th percentiles), those in the low intake group (≤10th percentile) had an elevated risk of their sons having hypospadias (multivariable-adjusted OR = 2.8, 95{\%} confidence interval = 1.4-5.8). Adverse or beneficial effects of genistein on hypospadias were not observed in the high intake group (≥90th percentile) (OR = 0.9, 95{\%} confidence interval = 0.4-2.4). Conclusion: Low maternal intake of isoflavone in early pregnancy was associated with an elevated risk of hypospadias.",
author = "{The Japan Environment and Children's Study Group} and Takehiro Michikawa and Shin Yamazaki and Masaji Ono and Tatsuo Kuroda and Nakayama, {Shoji F.} and Eiko Suda and Tomohiko Isobe and Miyuki Iwai-Shimada and Yayoi Kobayashi and Junzo Yonemoto and Kenji Tamura and Toshihiro Kawamoto and Hiroshi Nitta",
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T1 - Isoflavone Intake in Early Pregnancy and Hypospadias in the Japan Environment and Children's Study

AU - The Japan Environment and Children's Study Group

AU - Michikawa, Takehiro

AU - Yamazaki, Shin

AU - Ono, Masaji

AU - Kuroda, Tatsuo

AU - Nakayama, Shoji F.

AU - Suda, Eiko

AU - Isobe, Tomohiko

AU - Iwai-Shimada, Miyuki

AU - Kobayashi, Yayoi

AU - Yonemoto, Junzo

AU - Tamura, Kenji

AU - Kawamoto, Toshihiro

AU - Nitta, Hiroshi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: To explore the association between isoflavone intake in early pregnancy (the critical window of masculinisation) and hypospadias. Since oestrogen is likely to contribute to the differentiation of male external genitalia, dietary intake of isoflavone, which has a similar structure to human oestrogen, may be associated with the occurrence of hypospadias. However, there has been little evidence of this association. Materials and Methods: We used data of a nationwide birth cohort study, which recruited women as early in pregnancy as possible throughout Japan between 2011 and 2014. From the response to a self-administered food-frequency questionnaire, the daily intake of genistein (as a representative for isoflavone) was estimated. Information on hypospadias cases that were diagnosed until the first month after birth was obtained from medical records. Odds ratios (ORs) of hypospadias were estimated using a logistic regression model. Results: Among 41,578 mothers, who delivered singleton live male births, the median genistein intake was 15.3 mg/day, and a total of 51 cases of hypospadias were identified. Compared with mothers in the reference group (genistein intake 11th-89th percentiles), those in the low intake group (≤10th percentile) had an elevated risk of their sons having hypospadias (multivariable-adjusted OR = 2.8, 95% confidence interval = 1.4-5.8). Adverse or beneficial effects of genistein on hypospadias were not observed in the high intake group (≥90th percentile) (OR = 0.9, 95% confidence interval = 0.4-2.4). Conclusion: Low maternal intake of isoflavone in early pregnancy was associated with an elevated risk of hypospadias.

AB - Objective: To explore the association between isoflavone intake in early pregnancy (the critical window of masculinisation) and hypospadias. Since oestrogen is likely to contribute to the differentiation of male external genitalia, dietary intake of isoflavone, which has a similar structure to human oestrogen, may be associated with the occurrence of hypospadias. However, there has been little evidence of this association. Materials and Methods: We used data of a nationwide birth cohort study, which recruited women as early in pregnancy as possible throughout Japan between 2011 and 2014. From the response to a self-administered food-frequency questionnaire, the daily intake of genistein (as a representative for isoflavone) was estimated. Information on hypospadias cases that were diagnosed until the first month after birth was obtained from medical records. Odds ratios (ORs) of hypospadias were estimated using a logistic regression model. Results: Among 41,578 mothers, who delivered singleton live male births, the median genistein intake was 15.3 mg/day, and a total of 51 cases of hypospadias were identified. Compared with mothers in the reference group (genistein intake 11th-89th percentiles), those in the low intake group (≤10th percentile) had an elevated risk of their sons having hypospadias (multivariable-adjusted OR = 2.8, 95% confidence interval = 1.4-5.8). Adverse or beneficial effects of genistein on hypospadias were not observed in the high intake group (≥90th percentile) (OR = 0.9, 95% confidence interval = 0.4-2.4). Conclusion: Low maternal intake of isoflavone in early pregnancy was associated with an elevated risk of hypospadias.

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