Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish

Yoshiaki Kubota, Yuichi Oike, Shinya Satoh, Yoko Tabata, Yuichi Niikura, Toru Morisada, Masaki Akao, Takashi Urano, Yasuhiro Ito, Takeshi Miyamoto, Sumiko Watanabe, Toshio Suda

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Angiopoietin-like proteins (Angptls) are known to possess biological activities not only in the vascular system, but in the other mammalian tissues; however, their expression patterns and function in embryogenesis have not been extensively characterized. Here, we identify three zebrafish genes (Zangptl1, Zangptl2 and Zangptl6) highly homologous to mammalian Angptl1/ARP1, Angptl2/ARP2 and Angptl6/AGF, and describe their adult and embryonic temporal and spatial expression patterns. Zangptl1 is expressed faintly in the somites, while Zangptl2 is first detected in the yolk sac extension, spinal cord and branchial arches and is later expressed in the liver primordium and pectoral fin buds. Zangptl6 is expressed in the notochord. In addition to its embryonic expression, Zangptl2 is induced in adult fish during fin regeneration.

Original languageEnglish
Pages (from-to)679-685
Number of pages7
JournalGene Expression Patterns
Volume5
Issue number5
DOIs
Publication statusPublished - 2005 Jun

Fingerprint

Angiopoietins
Branchial Region
Notochord
Somites
Yolk Sac
Zebrafish
Embryonic Development
Blood Vessels
Regeneration
Spinal Cord
Fishes
Gene Expression
Liver
Genes
Proteins

Keywords

  • AGF
  • Angiopoietin
  • Angptl
  • Angptl1
  • Angptl2
  • Angptl6
  • ARP
  • ARP1
  • ARP2
  • Blastema
  • Branchial arch
  • Danio rerio
  • Fin bud
  • Fin regeneration
  • Liver
  • Notochord
  • Somite
  • Spinal cord
  • Yolk sac extension
  • Zebrafish

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish. / Kubota, Yoshiaki; Oike, Yuichi; Satoh, Shinya; Tabata, Yoko; Niikura, Yuichi; Morisada, Toru; Akao, Masaki; Urano, Takashi; Ito, Yasuhiro; Miyamoto, Takeshi; Watanabe, Sumiko; Suda, Toshio.

In: Gene Expression Patterns, Vol. 5, No. 5, 06.2005, p. 679-685.

Research output: Contribution to journalArticle

Kubota, Y, Oike, Y, Satoh, S, Tabata, Y, Niikura, Y, Morisada, T, Akao, M, Urano, T, Ito, Y, Miyamoto, T, Watanabe, S & Suda, T 2005, 'Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish', Gene Expression Patterns, vol. 5, no. 5, pp. 679-685. https://doi.org/10.1016/j.modgep.2005.02.006
Kubota, Yoshiaki ; Oike, Yuichi ; Satoh, Shinya ; Tabata, Yoko ; Niikura, Yuichi ; Morisada, Toru ; Akao, Masaki ; Urano, Takashi ; Ito, Yasuhiro ; Miyamoto, Takeshi ; Watanabe, Sumiko ; Suda, Toshio. / Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish. In: Gene Expression Patterns. 2005 ; Vol. 5, No. 5. pp. 679-685.
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