Isolation and structure of koshikalide, a 14-membered macrolide from the marine cyanobacterium Lyngbya sp.

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A 14-membered macrolide, koshikalide (1), was isolated from the marine cyanobacterium Lyngbya sp., and its planar structure was elucidated by spectroscopic analysis. The relative stereochemistry of C-11 and C-13 was elucidated by NOESY experiments and by an analysis of 1H-1H coupling constants. Koshikalide (1) exhibited weak cytotoxicity against HeLa S3 cells.

Original languageEnglish
Pages (from-to)959-960
Number of pages2
JournalTetrahedron Letters
Issue number6
Publication statusPublished - 2010 Feb 10


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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