Isolation and structure of koshikalide, a 14-membered macrolide from the marine cyanobacterium Lyngbya sp.

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Abstract

A 14-membered macrolide, koshikalide (1), was isolated from the marine cyanobacterium Lyngbya sp., and its planar structure was elucidated by spectroscopic analysis. The relative stereochemistry of C-11 and C-13 was elucidated by NOESY experiments and by an analysis of 1H-1H coupling constants. Koshikalide (1) exhibited weak cytotoxicity against HeLa S3 cells.

Original languageEnglish
Pages (from-to)959-960
Number of pages2
JournalTetrahedron Letters
Volume51
Issue number6
DOIs
Publication statusPublished - 2010 Feb 10

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Stereochemistry
Spectroscopic analysis
Macrolides
Cyanobacteria
Cytotoxicity
HeLa Cells
Experiments

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Isolation and structure of koshikalide, a 14-membered macrolide from the marine cyanobacterium Lyngbya sp. / Iwasaki, Arihiro; Teruya, Toshiaki; Suenaga, Kiyotake.

In: Tetrahedron Letters, Vol. 51, No. 6, 10.02.2010, p. 959-960.

Research output: Contribution to journalArticle

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