Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes

Shinichiro Okamoto, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC50 values of 8.1 and 9.0 μM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.

Original languageEnglish
Pages (from-to)2719-2725
Number of pages7
JournalJournal of Natural Products
Volume78
Issue number11
DOIs
Publication statusPublished - 2015 Nov 25

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

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