Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides

Maho Morita, Osamu Ohno, Toshiaki Teruya, Takao Yamori, Toshiyasu Inuzuka, Kiyotake Suenaga

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyasides B (3), C (4), and D (5), novel analogs of biselyngbyaside (1) and biselyngbyolide A (2). The gross structures of 3-5 were determined by NMR spectral analyses, and their stereochemistries were established based on NOESY spectra and CD data. Biselyngbyasides (1-3) showed growth-inhibitory activity and apoptosis-inducing activity against both HeLa S 3 cells and HL60 cells. The fura-2 method revealed that biselyngbyasides (1-3) increased the cytosolic Ca 2+ concentration in HeLa S 3 cells.

Original languageEnglish
Pages (from-to)5984-5990
Number of pages7
JournalTetrahedron
Volume68
Issue number30
DOIs
Publication statusPublished - 2012 Jul 29

Keywords

  • Apoptosis
  • Biselyngbyaside
  • Calcium
  • Cyanobacteria
  • Marine natural products

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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