Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides

Maho Morita, Osamu Ohno, Toshiaki Teruya, Takao Yamori, Toshiyasu Inuzuka, Kiyotake Suenaga

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyasides B (3), C (4), and D (5), novel analogs of biselyngbyaside (1) and biselyngbyolide A (2). The gross structures of 3-5 were determined by NMR spectral analyses, and their stereochemistries were established based on NOESY spectra and CD data. Biselyngbyasides (1-3) showed growth-inhibitory activity and apoptosis-inducing activity against both HeLa S 3 cells and HL60 cells. The fura-2 method revealed that biselyngbyasides (1-3) increased the cytosolic Ca 2+ concentration in HeLa S 3 cells.

Original languageEnglish
Pages (from-to)5984-5990
Number of pages7
JournalTetrahedron
Volume68
Issue number30
DOIs
Publication statusPublished - 2012 Jul 29

Fingerprint

Cyanobacteria
Bioactivity
Stereochemistry
Bioassay
Fura-2
HL-60 Cells
Fractionation
Biological Assay
Nuclear magnetic resonance
Apoptosis
biselyngbyaside
Growth

Keywords

  • Apoptosis
  • Biselyngbyaside
  • Calcium
  • Cyanobacteria
  • Marine natural products

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides. / Morita, Maho; Ohno, Osamu; Teruya, Toshiaki; Yamori, Takao; Inuzuka, Toshiyasu; Suenaga, Kiyotake.

In: Tetrahedron, Vol. 68, No. 30, 29.07.2012, p. 5984-5990.

Research output: Contribution to journalArticle

Morita, Maho ; Ohno, Osamu ; Teruya, Toshiaki ; Yamori, Takao ; Inuzuka, Toshiyasu ; Suenaga, Kiyotake. / Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides. In: Tetrahedron. 2012 ; Vol. 68, No. 30. pp. 5984-5990.
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