Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita

N. Takada, M. Watanabe, A. Yamada, K. Suenaga, K. Yamada, K. Ueda, D. Uemura

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines.

Original languageEnglish
Pages (from-to)356-359
Number of pages4
JournalJournal of Natural Products
Volume64
Issue number3
DOIs
Publication statusPublished - 2001 Apr 11
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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