Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita

N. Takada, M. Watanabe, A. Yamada, Kiyotake Suenaga, K. Yamada, K. Ueda, D. Uemura

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines.

Original languageEnglish
Pages (from-to)356-359
Number of pages4
JournalJournal of Natural Products
Volume64
Issue number3
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Plakortis
Spectroscopic analysis
Porifera
Cytotoxicity
cytotoxicity
Cells
cell lines
Cell Line
Degradation
degradation
Neoplasms
methodology
haterumadioxin B
haterumadioxin A
neoplasm cells

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita. / Takada, N.; Watanabe, M.; Yamada, A.; Suenaga, Kiyotake; Yamada, K.; Ueda, K.; Uemura, D.

In: Journal of Natural Products, Vol. 64, No. 3, 2001, p. 356-359.

Research output: Contribution to journalArticle

Takada, N. ; Watanabe, M. ; Yamada, A. ; Suenaga, Kiyotake ; Yamada, K. ; Ueda, K. ; Uemura, D. / Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita. In: Journal of Natural Products. 2001 ; Vol. 64, No. 3. pp. 356-359.
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