Isolation and structures of haterumalides NA, NB, NC, ND, and NE, novel macrolides from an Okinawan sponge Ircinia sp.

Noboru Takada, Hiroko Sato, Kiyotake Suenaga, Hirokazu Arimoto, Kaoru Yamada, Katsuhiro Ueda, Daisuke Uemura

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

Novel macrolides, haterumalides NA (1), NB (2), NC (3), ND (4), and NE (5), were isolated from an Okinawan sponge Ircinia sp. The absolute stereostructure of 1 was determined by spectroscopic analysis and modified Mosher's method. Haterumalide NA (1) showed cytotoxicity against P388 cells and acute toxicity against mice.

Original languageEnglish
Pages (from-to)6309-6312
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number34
DOIs
Publication statusPublished - 1999 Aug 20
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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