Isolation and synthesis of a new aromatic compound, brefelamide, from Dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells

Haruhisa Kikuchi, Yoshinori Saito, Jun'ichi Sekiya, Yumiko Okano, Masaki Saito, Norimichi Nakahata, Yuzuru Kubohara, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

We have explored the diversity of secondary metabolites produced by cellular slime molds to examine the possible use of such cellular slime molds as a resource for novel drug development. A new aromatic amide, brefelamide (1), was isolated from methanol extracts of the fruiting bodies of Dictyostelium brefeldianum and D. giganteum. The structure of 1 was determined by spectral means including EIMS and 1H and 13C NMR. The total synthesis of 1 was carried out to confirm the structure and obtain sufficient samples for performing biological evaluation. Interestingly, compound 1 inhibited the cellular proliferation of 1321N1 human astrocytoma cells.

Original languageEnglish
Pages (from-to)8854-8858
Number of pages5
JournalJournal of Organic Chemistry
Volume70
Issue number22
DOIs
Publication statusPublished - 2005 Oct 28
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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