Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei

Keiji Yuki, Mariko Ikeda, Kenji Miyamoto, Osamu Ohno, Kaoru Yamada, Daisuke Uemura

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5 Citations (Scopus)


An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

Original languageEnglish
Pages (from-to)1233-1235
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number6
Publication statusPublished - 2012 Jun 29



  • 3T3-L1 murine adipocytes
  • Fat accumulation
  • Inhibitor
  • Valeriana fauriei

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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