Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei

Keiji Yuki, Mariko Ikeda, Kenji Miyamoto, Osamu Ohno, Kaoru Yamada, Daisuke Uemura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

Original languageEnglish
Pages (from-to)1233-1235
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number6
DOIs
Publication statusPublished - 2012

Fingerprint

Valerian
Fats
Conjugated Linoleic Acids
Adipocytes
Derivatives
octadecadienoic acid

Keywords

  • 3T3-L1 murine adipocytes
  • Fat accumulation
  • Inhibitor
  • Valeriana fauriei

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei. / Yuki, Keiji; Ikeda, Mariko; Miyamoto, Kenji; Ohno, Osamu; Yamada, Kaoru; Uemura, Daisuke.

In: Bioscience, Biotechnology and Biochemistry, Vol. 76, No. 6, 2012, p. 1233-1235.

Research output: Contribution to journalArticle

Yuki, Keiji ; Ikeda, Mariko ; Miyamoto, Kenji ; Ohno, Osamu ; Yamada, Kaoru ; Uemura, Daisuke. / Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei. In: Bioscience, Biotechnology and Biochemistry. 2012 ; Vol. 76, No. 6. pp. 1233-1235.
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