Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase

Shingo Yoshikawa, Issei Miyamoto, Jun Aruga, Teiichi Furuichi, Hideyuki Okano, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have isolated and characterized a new guanylyl cyclase gene (dgc1) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian soluble-type guanylyl cyclase α subunit. The cyclase catalytic domain was highly conserved between the mammalian and Drosophila guanylyl cyclases. The dgc1 mRNA was detected in wild-type heads but not in bodies, and its level was reduced in the mutant eyes absent (eya), indicating that dgc1 is preferentially expressed in the CNS and in the eye. The enriched distribution in the eye suggests that dgc1 may have a role in phototransduction.

Original languageEnglish
Pages (from-to)1570-1573
Number of pages4
JournalJournal of Neurochemistry
Volume60
Issue number4
Publication statusPublished - 1993 Apr
Externally publishedYes

Fingerprint

Gene encoding
Guanylate Cyclase
Drosophila
Head
Light Signal Transduction
Genes
Amino Acids
Amino Acid Sequence
Catalytic Domain
Messenger RNA

Keywords

  • CNS
  • Drosophila dgc1 gene
  • Guanylyl cyclase
  • Phototransduction

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Yoshikawa, S., Miyamoto, I., Aruga, J., Furuichi, T., Okano, H., & Mikoshiba, K. (1993). Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. Journal of Neurochemistry, 60(4), 1570-1573.

Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. / Yoshikawa, Shingo; Miyamoto, Issei; Aruga, Jun; Furuichi, Teiichi; Okano, Hideyuki; Mikoshiba, Katsuhiko.

In: Journal of Neurochemistry, Vol. 60, No. 4, 04.1993, p. 1570-1573.

Research output: Contribution to journalArticle

Yoshikawa, S, Miyamoto, I, Aruga, J, Furuichi, T, Okano, H & Mikoshiba, K 1993, 'Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase', Journal of Neurochemistry, vol. 60, no. 4, pp. 1570-1573.
Yoshikawa S, Miyamoto I, Aruga J, Furuichi T, Okano H, Mikoshiba K. Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. Journal of Neurochemistry. 1993 Apr;60(4):1570-1573.
Yoshikawa, Shingo ; Miyamoto, Issei ; Aruga, Jun ; Furuichi, Teiichi ; Okano, Hideyuki ; Mikoshiba, Katsuhiko. / Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. In: Journal of Neurochemistry. 1993 ; Vol. 60, No. 4. pp. 1570-1573.
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