Abstract: We have isolated and characterized a new guanylyl cyclase gene (dgcl) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian solubletype guanylyl cyclase α subunit. The cyclase catalytic domain was highly conserved between the mammalian and Drosophila guanylyl cyclases. The dgcl mRNA was detected in wild‐type heads but not in bodies, and its level was reduced in the mutant eyes absent (eya), indicating that dgcl is preferentially expressed in the CNS and in the eye. The enriched distribution in the eye suggests that dgcl may have a role in phototransduction.
|Number of pages||4|
|Journal||Journal of Neurochemistry|
|Publication status||Published - 1993 Apr|
- Drosophila dgcl gene
- Guanylyl cyclase
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience