Isolation of a new indole alkaloid, pendolmycin, from nocardiopsis

Takashi Yamashita; Masaya Imoto; Kunio Isshiki; Tsutomu Sawa; Hiroshi Naganawa; Shogo Kurasawa; Kazuo Umezawa; Bao Quan Zhu

doi:10.1021/np50060a022

Isolation of a new indole alkaloid, pendolmycin, from nocardiopsis

Takashi Yamashita, Masaya Imoto, Kunio Isshiki, Tsutomu Sawa, Hiroshi Naganawa, Shogo Kurasawa, Kazuo Umezawa, Bao Quan Zhu

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

—A new indole alkaloid, pendolmycin {1}, was isolated from NocardioPsis strain SA1715 as an inhibitor of epidermal-growth-factor-induced phosphatidylinositol turn-over in A431 cells. The structure of pendolmycin is closely related to that of teleocidin B {2} and of lyngbyatoxin A [3]. Pendolmycin may be a biosynthetic intermediate of these alkaloids.

Original language	English
Pages (from-to)	1184-1187
Number of pages	4
Journal	Journal of Natural Products
Volume	51
Issue number	6
DOIs	https://doi.org/10.1021/np50060a022
Publication status	Published - 1988 Nov
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50060a022

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abstract = "—A new indole alkaloid, pendolmycin {1}, was isolated from NocardioPsis strain SA1715 as an inhibitor of epidermal-growth-factor-induced phosphatidylinositol turn-over in A431 cells. The structure of pendolmycin is closely related to that of teleocidin B {2} and of lyngbyatoxin A [3]. Pendolmycin may be a biosynthetic intermediate of these alkaloids.",

author = "Takashi Yamashita and Masaya Imoto and Kunio Isshiki and Tsutomu Sawa and Hiroshi Naganawa and Shogo Kurasawa and Kazuo Umezawa and Zhu, {Bao Quan}",

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AU - Yamashita, Takashi

AU - Imoto, Masaya

AU - Isshiki, Kunio

AU - Sawa, Tsutomu

AU - Naganawa, Hiroshi

AU - Kurasawa, Shogo

AU - Umezawa, Kazuo

AU - Zhu, Bao Quan

PY - 1988/11

Y1 - 1988/11

N2 - —A new indole alkaloid, pendolmycin {1}, was isolated from NocardioPsis strain SA1715 as an inhibitor of epidermal-growth-factor-induced phosphatidylinositol turn-over in A431 cells. The structure of pendolmycin is closely related to that of teleocidin B {2} and of lyngbyatoxin A [3]. Pendolmycin may be a biosynthetic intermediate of these alkaloids.

AB - —A new indole alkaloid, pendolmycin {1}, was isolated from NocardioPsis strain SA1715 as an inhibitor of epidermal-growth-factor-induced phosphatidylinositol turn-over in A431 cells. The structure of pendolmycin is closely related to that of teleocidin B {2} and of lyngbyatoxin A [3]. Pendolmycin may be a biosynthetic intermediate of these alkaloids.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

Isolation of a new indole alkaloid, pendolmycin, from nocardiopsis

Abstract

ASJC Scopus subject areas

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