Isolation of a new indole alkaloid, pendolmycin, from Nocardiopsis

Takashi Yamashita, Masaya Imoto, Kunio Isshiki, Tsutomu Sawa, Hiroshi Naganawa, Shogo Kurasawa, Bao Quan Zhu, Kazuo Umezawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A new indole alkaloid, pendolmycin [1], was isolated from Nocardiopsis strain SA1715 as an inhibitor of epidermal-growth-factor-induced phosphatidylinositol turnover in A431 cells. The structure of pendolmycin is closely related to that of teleocidin B [2] and of lyngbyatoxin A [3]. Pendolmycin may be a biosynthetic intermediate of these alkaloids.

Original languageEnglish
Pages (from-to)1184-1187
Number of pages4
JournalJournal of Natural Products
Volume51
Issue number6
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Nocardiopsis
Indole Alkaloids
indole alkaloids
epidermal growth factor
phosphatidylinositols
alkaloids
cells
Phosphatidylinositols
Alkaloids
Epidermal Growth Factor
pendolmycin

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Yamashita, T., Imoto, M., Isshiki, K., Sawa, T., Naganawa, H., Kurasawa, S., ... Umezawa, K. (1988). Isolation of a new indole alkaloid, pendolmycin, from Nocardiopsis. Journal of Natural Products, 51(6), 1184-1187.

Isolation of a new indole alkaloid, pendolmycin, from Nocardiopsis. / Yamashita, Takashi; Imoto, Masaya; Isshiki, Kunio; Sawa, Tsutomu; Naganawa, Hiroshi; Kurasawa, Shogo; Zhu, Bao Quan; Umezawa, Kazuo.

In: Journal of Natural Products, Vol. 51, No. 6, 1988, p. 1184-1187.

Research output: Contribution to journalArticle

Yamashita, T, Imoto, M, Isshiki, K, Sawa, T, Naganawa, H, Kurasawa, S, Zhu, BQ & Umezawa, K 1988, 'Isolation of a new indole alkaloid, pendolmycin, from Nocardiopsis', Journal of Natural Products, vol. 51, no. 6, pp. 1184-1187.
Yamashita T, Imoto M, Isshiki K, Sawa T, Naganawa H, Kurasawa S et al. Isolation of a new indole alkaloid, pendolmycin, from Nocardiopsis. Journal of Natural Products. 1988;51(6):1184-1187.
Yamashita, Takashi ; Imoto, Masaya ; Isshiki, Kunio ; Sawa, Tsutomu ; Naganawa, Hiroshi ; Kurasawa, Shogo ; Zhu, Bao Quan ; Umezawa, Kazuo. / Isolation of a new indole alkaloid, pendolmycin, from Nocardiopsis. In: Journal of Natural Products. 1988 ; Vol. 51, No. 6. pp. 1184-1187.
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