Isolation of a new indole alkaloid, pendolmycin, from nocardiopsis

Takashi Yamashita, Masaya Imoto, Kunio Isshiki, Tsutomu Sawa, Hiroshi Naganawa, Shogo Kurasawa, Kazuo Umezawa, Bao Quan Zhu

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


—A new indole alkaloid, pendolmycin {1}, was isolated from NocardioPsis strain SA1715 as an inhibitor of epidermal-growth-factor-induced phosphatidylinositol turn-over in A431 cells. The structure of pendolmycin is closely related to that of teleocidin B {2} and of lyngbyatoxin A [3]. Pendolmycin may be a biosynthetic intermediate of these alkaloids.

Original languageEnglish
Pages (from-to)1184-1187
Number of pages4
JournalJournal of Natural Products
Issue number6
Publication statusPublished - 1988 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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