Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

Chino Matsui; Yoko Ikeda; Hironobu Iinuma; Nobuaki Kushida; Takao Kunisada; Siro Simizu; Kazuo Umezawa

doi:10.1038/ja.2014.63

Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

Chino Matsui, Yoko Ikeda, Hironobu Iinuma, Nobuaki Kushida, Takao Kunisada, Siro Simizu, Kazuo Umezawa

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We have screened microbial culture filtrates for nitrogen monoxide (NO) production inhibitors using mouse macrophage cell line RAW264.7. As a result, paxilline, 21-isopentenylpaxilline and a novel analog of paxilline have been isolated from the culture filtrate of fungus Eupenicillium shearii. The novel analog possesses an additional dihydropyran ring, and was named as pyrapaxilline. This compound inhibited the NO production with lower toxicity than paxilline.

Original language	English
Pages (from-to)	787-790
Number of pages	4
Journal	Journal of Antibiotics
Volume	67
Issue number	11
DOIs	https://doi.org/10.1038/ja.2014.63
Publication status	Published - 2014 Nov 1

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/ja.2014.63

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abstract = "We have screened microbial culture filtrates for nitrogen monoxide (NO) production inhibitors using mouse macrophage cell line RAW264.7. As a result, paxilline, 21-isopentenylpaxilline and a novel analog of paxilline have been isolated from the culture filtrate of fungus Eupenicillium shearii. The novel analog possesses an additional dihydropyran ring, and was named as pyrapaxilline. This compound inhibited the NO production with lower toxicity than paxilline.",

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AU - Kunisada, Takao

AU - Simizu, Siro

AU - Umezawa, Kazuo

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AB - We have screened microbial culture filtrates for nitrogen monoxide (NO) production inhibitors using mouse macrophage cell line RAW264.7. As a result, paxilline, 21-isopentenylpaxilline and a novel analog of paxilline have been isolated from the culture filtrate of fungus Eupenicillium shearii. The novel analog possesses an additional dihydropyran ring, and was named as pyrapaxilline. This compound inhibited the NO production with lower toxicity than paxilline.

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Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

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