Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

Chino Matsui, Yoko Ikeda, Hironobu Iinuma, Nobuaki Kushida, Takao Kunisada, Siro Simizu, Kazuo Umezawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have screened microbial culture filtrates for nitrogen monoxide (NO) production inhibitors using mouse macrophage cell line RAW264.7. As a result, paxilline, 21-isopentenylpaxilline and a novel analog of paxilline have been isolated from the culture filtrate of fungus Eupenicillium shearii. The novel analog possesses an additional dihydropyran ring, and was named as pyrapaxilline. This compound inhibited the NO production with lower toxicity than paxilline.

Original languageEnglish
Pages (from-to)787-790
Number of pages4
JournalJournal of Antibiotics
Volume67
Issue number11
DOIs
Publication statusPublished - 2014 Nov 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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