Isolation of alkamides with death receptor-enhancing activities from Piper Chaba

Hoque Tahmina; Kazufumi Toume; Midori A. Arai; Samir K. Sadhu; Firoj Ahmed; Masami Ishibashi

doi:10.3987/COM-14-S(K)68

Isolation of alkamides with death receptor-enhancing activities from Piper Chaba

Hoque Tahmina, Kazufumi Toume, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.

Original language	English
Pages (from-to)	1317-1322
Number of pages	6
Journal	Heterocycles
Volume	90
Issue number	2
DOIs	https://doi.org/10.3987/COM-14-S(K)68
Publication status	Published - 2015
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Isolation of alkamides with death receptor-enhancing activities from Piper Chaba",

abstract = "In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.",

author = "Hoque Tahmina and Kazufumi Toume and Arai, {Midori A.} and Sadhu, {Samir K.} and Firoj Ahmed and Masami Ishibashi",

note = "Publisher Copyright: {\textcopyright} 2015 The Japan Institute of Heterocyclic Chemistry.",

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T1 - Isolation of alkamides with death receptor-enhancing activities from Piper Chaba

AU - Tahmina, Hoque

AU - Toume, Kazufumi

AU - Arai, Midori A.

AU - Sadhu, Samir K.

AU - Ahmed, Firoj

AU - Ishibashi, Masami

PY - 2015

Y1 - 2015

N2 - In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.

AB - In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.

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ER -

Isolation of alkamides with death receptor-enhancing activities from Piper Chaba

Abstract

ASJC Scopus subject areas

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