Isolation of alkamides with death receptor-enhancing activities from Piper Chaba

Hoque Tahmina, Kazufumi Toume, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.

Original languageEnglish
Pages (from-to)1317-1322
Number of pages6
JournalHeterocycles
Volume90
Issue number2
DOIs
Publication statusPublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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