In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.
|Number of pages||6|
|Publication status||Published - 2015|
ASJC Scopus subject areas
- Analytical Chemistry
- Organic Chemistry