Isolation of C 11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.

Takayuki Ogi, Palupi Margiastuti, Toshiaki Teruya, Junsei Taira, Kiyotake Suenaga, Katsuhiro Ueda

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A series of new C 11 cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

Original languageEnglish
Pages (from-to)816-832
Number of pages17
JournalMarine Drugs
Volume7
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

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Keywords

  • Cyclopentenone
  • Cytotoxicity
  • Didemnenone
  • Diplosoma
  • Lissoclinum

ASJC Scopus subject areas

  • Drug Discovery

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