Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.

Takayuki Ogi; Palupi Margiastuti; Toshiaki Teruya; Junsei Taira; Kiyotake Suenaga; Katsuhiro Ueda

doi:10.3390/md7040816

Isolation of C₁₁ cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.

Takayuki Ogi, Palupi Margiastuti, Toshiaki Teruya, Junsei Taira, Kiyotake Suenaga, Katsuhiro Ueda

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A series of new C₁₁ cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

Original language	English
Pages (from-to)	816-832
Number of pages	17
Journal	Marine Drugs
Volume	7
Issue number	4
DOIs	https://doi.org/10.3390/md7040816
Publication status	Published - 2009 Dec

Keywords

Cyclopentenone
Cytotoxicity
Didemnenone
Diplosoma
Lissoclinum

ASJC Scopus subject areas

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/md7040816

Cite this

@article{dc291b5c0c174570b3f6bb47f07a0ed9,

title = "Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.",

abstract = "A series of new C11 cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).",

keywords = "Cyclopentenone, Cytotoxicity, Didemnenone, Diplosoma, Lissoclinum",

author = "Takayuki Ogi and Palupi Margiastuti and Toshiaki Teruya and Junsei Taira and Kiyotake Suenaga and Katsuhiro Ueda",

year = "2009",

month = dec,

doi = "10.3390/md7040816",

language = "English",

volume = "7",

pages = "816--832",

journal = "Marine Drugs",

issn = "1660-3397",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

}

TY - JOUR

T1 - Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.

AU - Ogi, Takayuki

AU - Margiastuti, Palupi

AU - Teruya, Toshiaki

AU - Taira, Junsei

AU - Suenaga, Kiyotake

AU - Ueda, Katsuhiro

PY - 2009/12

Y1 - 2009/12

N2 - A series of new C11 cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

AB - A series of new C11 cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

KW - Cyclopentenone

KW - Cytotoxicity

KW - Didemnenone

KW - Diplosoma

KW - Lissoclinum

UR - http://www.scopus.com/inward/record.url?scp=75149198747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75149198747&partnerID=8YFLogxK

U2 - 10.3390/md7040816

DO - 10.3390/md7040816

M3 - Article

C2 - 20098612

AN - SCOPUS:75149198747

SN - 1660-3397

VL - 7

SP - 816

EP - 832

JO - Marine Drugs

JF - Marine Drugs

IS - 4

ER -