Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of Gelsemium alkaloids for A431 epidermoid carcinoma cells

Mariko Kitajima; Tomonori Nakamura; Noriyuki Kogure; Mio Ogawa; Yuka Mitsuno; Kageyoshi Ono; Shingo Yano; Norio Aimi; Hiromitsu Takayama

doi:10.1021/np060016o

Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of Gelsemium alkaloids for A431 epidermoid carcinoma cells

Mariko Kitajima, Tomonori Nakamura, Noriyuki Kogure, Mio Ogawa, Yuka Mitsuno, Kageyoshi Ono, Shingo Yano, Norio Aimi, Hiromitsu Takayama

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

Four new gelsedine-type indole alkaloids (1-4) were isolated from the leaves of Gelsemium elegans, together with 11 known alkaloids. The structures were determined as 14-acetoxygelsenicine (1), 14-acetoxy-15-hydroxygelsenicine (2), 14-hydroxy-19-oxogelsenicine (3), and 14-acetoxygelselegine (4), respectively, by spectroscopic analysis. The cytotoxic effects of 14 Gelsemium alkaloids including two new compounds (1, 2) were evaluated using the A431 human epidermoid carcinoma cell line. Of these, the gelsedine-type alkaloids 14-acetoxygelsenicine (1), 14,15-dihydroxygelsenicine (5), gelsedine (7), and gelsemicine (8) showed potent cytotoxic effects.

Original language	English
Pages (from-to)	715-718
Number of pages	4
Journal	Journal of Natural Products
Volume	69
Issue number	4
DOIs	https://doi.org/10.1021/np060016o
Publication status	Published - 2006 Apr
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np060016o

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Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of Gelsemium alkaloids for A431 epidermoid carcinoma cells. / Kitajima, Mariko; Nakamura, Tomonori; Kogure, Noriyuki et al.

In: Journal of Natural Products, Vol. 69, No. 4, 04.2006, p. 715-718.

Research output: Contribution to journal › Article › peer-review

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abstract = "Four new gelsedine-type indole alkaloids (1-4) were isolated from the leaves of Gelsemium elegans, together with 11 known alkaloids. The structures were determined as 14-acetoxygelsenicine (1), 14-acetoxy-15-hydroxygelsenicine (2), 14-hydroxy-19-oxogelsenicine (3), and 14-acetoxygelselegine (4), respectively, by spectroscopic analysis. The cytotoxic effects of 14 Gelsemium alkaloids including two new compounds (1, 2) were evaluated using the A431 human epidermoid carcinoma cell line. Of these, the gelsedine-type alkaloids 14-acetoxygelsenicine (1), 14,15-dihydroxygelsenicine (5), gelsedine (7), and gelsemicine (8) showed potent cytotoxic effects.",

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AU - Kogure, Noriyuki

AU - Ogawa, Mio

AU - Mitsuno, Yuka

AU - Ono, Kageyoshi

AU - Yano, Shingo

AU - Aimi, Norio

AU - Takayama, Hiromitsu

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Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of Gelsemium alkaloids for A431 epidermoid carcinoma cells

Abstract

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