Isolation of monovalerianester a, an inhibitor of fat accumulation, from valeriana fauriei

Keiji Yuki; Mariko Ikeda; Shosuke Yoshida; Osamu Ohno; Kiyotake Suenaga; Kaoru Yamada; Daisuke Uemura; Kenji Miyamoto

doi:10.1177/1934578x1501000801

Isolation of monovalerianester a, an inhibitor of fat accumulation, from valeriana fauriei

Keiji Yuki, Mariko Ikeda, Shosuke Yoshida, Osamu Ohno, Kiyotake Suenaga, Kaoru Yamada, Daisuke Uemura, Kenji Miyamoto

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The rhizomes and roots of Valeriana fauriei were extracted with 80% aqueous ethanol. This extract was found to exhibit potent inhibitory effects on fat accumulation in 3T3-L1 murine adipocytes. After several steps of chromatographic purification, we succeeded in identifying monovalerianester A as an inhibitor of fat accumulation. Thus, monovalerianester A and the crude extract of the rhizomes and roots of V. fauriei may have therapeutic potential for the treatment of obesity.

Original language	English
Pages (from-to)	1333-1334
Number of pages	2
Journal	Natural product communications
Volume	10
Issue number	8
DOIs	https://doi.org/10.1177/1934578x1501000801
Publication status	Published - 2015 Aug

Keywords

3T3-L1 murine adipocytes
Fat accumulation
Inhibitor
Monovalerianester A
Valeriana fauriei

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578x1501000801

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abstract = "The rhizomes and roots of Valeriana fauriei were extracted with 80% aqueous ethanol. This extract was found to exhibit potent inhibitory effects on fat accumulation in 3T3-L1 murine adipocytes. After several steps of chromatographic purification, we succeeded in identifying monovalerianester A as an inhibitor of fat accumulation. Thus, monovalerianester A and the crude extract of the rhizomes and roots of V. fauriei may have therapeutic potential for the treatment of obesity.",

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year = "2015",

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doi = "10.1177/1934578x1501000801",

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volume = "10",

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T1 - Isolation of monovalerianester a, an inhibitor of fat accumulation, from valeriana fauriei

AU - Yuki, Keiji

AU - Ikeda, Mariko

AU - Yoshida, Shosuke

AU - Ohno, Osamu

AU - Suenaga, Kiyotake

AU - Yamada, Kaoru

AU - Uemura, Daisuke

AU - Miyamoto, Kenji

PY - 2015/8

Y1 - 2015/8

N2 - The rhizomes and roots of Valeriana fauriei were extracted with 80% aqueous ethanol. This extract was found to exhibit potent inhibitory effects on fat accumulation in 3T3-L1 murine adipocytes. After several steps of chromatographic purification, we succeeded in identifying monovalerianester A as an inhibitor of fat accumulation. Thus, monovalerianester A and the crude extract of the rhizomes and roots of V. fauriei may have therapeutic potential for the treatment of obesity.

AB - The rhizomes and roots of Valeriana fauriei were extracted with 80% aqueous ethanol. This extract was found to exhibit potent inhibitory effects on fat accumulation in 3T3-L1 murine adipocytes. After several steps of chromatographic purification, we succeeded in identifying monovalerianester A as an inhibitor of fat accumulation. Thus, monovalerianester A and the crude extract of the rhizomes and roots of V. fauriei may have therapeutic potential for the treatment of obesity.

KW - 3T3-L1 murine adipocytes

KW - Fat accumulation

KW - Inhibitor

KW - Monovalerianester A

KW - Valeriana fauriei

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SN - 1934-578X

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JO - Natural Product Communications

JF - Natural Product Communications

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ER -

Isolation of monovalerianester a, an inhibitor of fat accumulation, from valeriana fauriei

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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