Isolation of monovalerianester a, an inhibitor of fat accumulation, from valeriana fauriei

Keiji Yuki, Mariko Ikeda, Shosuke Yoshida, Osamu Ohno, Kiyotake Suenaga, Kaoru Yamada, Daisuke Uemura, Kenji Miyamoto

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The rhizomes and roots of Valeriana fauriei were extracted with 80% aqueous ethanol. This extract was found to exhibit potent inhibitory effects on fat accumulation in 3T3-L1 murine adipocytes. After several steps of chromatographic purification, we succeeded in identifying monovalerianester A as an inhibitor of fat accumulation. Thus, monovalerianester A and the crude extract of the rhizomes and roots of V. fauriei may have therapeutic potential for the treatment of obesity.

Original languageEnglish
Pages (from-to)1333-1334
Number of pages2
JournalNatural product communications
Volume10
Issue number8
DOIs
Publication statusPublished - 2015 Aug

Keywords

  • 3T3-L1 murine adipocytes
  • Fat accumulation
  • Inhibitor
  • Monovalerianester A
  • Valeriana fauriei

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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