Isolation of nabscessin C from nocardia abscessus IFM 10029T and A study on biosynthetic pathway for nabscessins

Shoko Hara; Yasumasa Hara; Midori A. Arai; Yoko Kusuya; Hiroki Takahashi; Takashi Yaguchi; Masami Ishibashi

doi:10.1248/cpb.c18-00430

Isolation of nabscessin C from nocardia abscessus IFM 10029^T and A study on biosynthetic pathway for nabscessins

Shoko Hara, Yasumasa Hara, Midori A. Arai, Yoko Kusuya, Hiroki Takahashi, Takashi Yaguchi, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A new aminocyclitol derivative, designated nabscessin C (1), was isolated from Nocardia abscessus IFM 10029^T. Nabcessin C is an isomer of nabscessins A (2) and B (3) with different positioning of the acyl group. Absolute configuration of nabscessin A was determined by conversion into the 2-deoxy-scyllo-inosamine pentaacetyl derivative (4) by hydrolysis and acetylation of 2. The biosynthetic pathway of nabscessins is proposed based on gene expression analysis.

Original language	English
Pages (from-to)	976-982
Number of pages	7
Journal	Chemical and Pharmaceutical Bulletin
Volume	66
Issue number	10
DOIs	https://doi.org/10.1248/cpb.c18-00430
Publication status	Published - 2018
Externally published	Yes

Keywords

Actinomycete
Aminocyclitol
Biosynthetic pathway
Nocardia

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.c18-00430

Cite this

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title = "Isolation of nabscessin C from nocardia abscessus IFM 10029T and A study on biosynthetic pathway for nabscessins",

abstract = "A new aminocyclitol derivative, designated nabscessin C (1), was isolated from Nocardia abscessus IFM 10029T. Nabcessin C is an isomer of nabscessins A (2) and B (3) with different positioning of the acyl group. Absolute configuration of nabscessin A was determined by conversion into the 2-deoxy-scyllo-inosamine pentaacetyl derivative (4) by hydrolysis and acetylation of 2. The biosynthetic pathway of nabscessins is proposed based on gene expression analysis.",

keywords = "Actinomycete, Aminocyclitol, Biosynthetic pathway, Nocardia",

author = "Shoko Hara and Yasumasa Hara and Arai, {Midori A.} and Yoko Kusuya and Hiroki Takahashi and Takashi Yaguchi and Masami Ishibashi",

note = "Funding Information: Acknowledgments This study was supported by JSPS KAKENHI Grant Number 17H03992 and the Strategic Priority Research Promotion Program of Chiba University, titled Publisher Copyright: {\textcopyright} 2018 The Pharmaceutical Society of Japan",

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T1 - Isolation of nabscessin C from nocardia abscessus IFM 10029T and A study on biosynthetic pathway for nabscessins

AU - Hara, Shoko

AU - Hara, Yasumasa

AU - Arai, Midori A.

AU - Kusuya, Yoko

AU - Takahashi, Hiroki

AU - Yaguchi, Takashi

AU - Ishibashi, Masami

N1 - Funding Information: Acknowledgments This study was supported by JSPS KAKENHI Grant Number 17H03992 and the Strategic Priority Research Promotion Program of Chiba University, titled Publisher Copyright: © 2018 The Pharmaceutical Society of Japan

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Y1 - 2018

N2 - A new aminocyclitol derivative, designated nabscessin C (1), was isolated from Nocardia abscessus IFM 10029T. Nabcessin C is an isomer of nabscessins A (2) and B (3) with different positioning of the acyl group. Absolute configuration of nabscessin A was determined by conversion into the 2-deoxy-scyllo-inosamine pentaacetyl derivative (4) by hydrolysis and acetylation of 2. The biosynthetic pathway of nabscessins is proposed based on gene expression analysis.

AB - A new aminocyclitol derivative, designated nabscessin C (1), was isolated from Nocardia abscessus IFM 10029T. Nabcessin C is an isomer of nabscessins A (2) and B (3) with different positioning of the acyl group. Absolute configuration of nabscessin A was determined by conversion into the 2-deoxy-scyllo-inosamine pentaacetyl derivative (4) by hydrolysis and acetylation of 2. The biosynthetic pathway of nabscessins is proposed based on gene expression analysis.

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KW - Aminocyclitol

KW - Biosynthetic pathway

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