Isolation of nabscessin C from nocardia abscessus IFM 10029T and A study on biosynthetic pathway for nabscessins

Shoko Hara, Yasumasa Hara, Midori A. Arai, Yoko Kusuya, Hiroki Takahashi, Takashi Yaguchi, Masami Ishibashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A new aminocyclitol derivative, designated nabscessin C (1), was isolated from Nocardia abscessus IFM 10029T. Nabcessin C is an isomer of nabscessins A (2) and B (3) with different positioning of the acyl group. Absolute configuration of nabscessin A was determined by conversion into the 2-deoxy-scyllo-inosamine pentaacetyl derivative (4) by hydrolysis and acetylation of 2. The biosynthetic pathway of nabscessins is proposed based on gene expression analysis.

Original languageEnglish
Pages (from-to)976-982
Number of pages7
JournalChemical and Pharmaceutical Bulletin
Volume66
Issue number10
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Keywords

  • Actinomycete
  • Aminocyclitol
  • Biosynthetic pathway
  • Nocardia

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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