ISOLATION of PEPTIDOLIPIN NA DERIVATIVES from the CULTURE of NOCARDIA ARTHRITIDIS IFM10035T in the PRESENCE of MOUSE MACROPHAGE CELLS

Yasumasa Hara, Daiki Tanimura, Teruhisa Manome, Midori A. Arai, Takashi Yaguchi, Masami Ishibashi

Research output: Contribution to journalArticlepeer-review

Abstract

We isolated two peptidolipin NA derivatives, L-Val (6) peptidolipin NA and peptidolipin NA, named as compounds 1 and 2, respectively. These compounds were produced in the co-culture extracts of Nocardia arthritidis IFM10035T and the mouse macrophage cell line J774.1, but not in the single culture of N. arthritidis. Among the two compounds along with nocarjamide (3) isolated from the co-culture of N. tenerifensis and J774.1, compounds 1 and 3 showed higher cytotoxicity against J774.1, with IC50 values of 116 μM and 25 μM, respectively. In addition, compound 1 showed a TRAIL-resistance-overcoming activity in the human gastric adenocarcinoma AGS cells.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalHeterocycles
Volume104
Issue number1
DOIs
Publication statusPublished - 2021

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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