Abstract
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) potently induces apoptosis in most cancer cells, but not in normal cells, and, thus, has attracted intense interest as a promising antitumor agent. Activity-guided fractionation of the culture broth of the actinomycete CKK1172 strain led to the isolation of the antibiotic resistomycin (1) using human gastric adenocarcinoma AGS cells. Compound 1 exhibited TRAIL resistance-overcoming activity at 2 μM with 38% more inhibition than a treatment with 1 alone (without TRAIL) in TRAIL-resistant AGS cells.
| Original language | English |
|---|---|
| Pages (from-to) | 65-66 |
| Number of pages | 2 |
| Journal | Natural product communications |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
Keywords
- Actinomycete
- Resistomycin
- TRAIL resistance-overcoming activity
ASJC Scopus subject areas
- Pharmacology
- Plant Science
- Drug Discovery
- Complementary and alternative medicine
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Liu, X., Arai, M. A., Toume, K., & Ishibashi, M. (2018). Isolation of resistomycin from a terrestrial actinomycete with trail resistance-overcoming activity. Natural product communications, 13(1), 65-66. https://doi.org/10.1177/1934578x1801300119