Abstract
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) potently induces apoptosis in most cancer cells, but not in normal cells, and, thus, has attracted intense interest as a promising antitumor agent. Activity-guided fractionation of the culture broth of the actinomycete CKK1172 strain led to the isolation of the antibiotic resistomycin (1) using human gastric adenocarcinoma AGS cells. Compound 1 exhibited TRAIL resistance-overcoming activity at 2 μM with 38% more inhibition than a treatment with 1 alone (without TRAIL) in TRAIL-resistant AGS cells.
Original language | English |
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Pages (from-to) | 65-66 |
Number of pages | 2 |
Journal | Natural product communications |
Volume | 13 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2018 Jan |
Externally published | Yes |
Keywords
- Actinomycete
- Resistomycin
- TRAIL resistance-overcoming activity
ASJC Scopus subject areas
- Pharmacology
- Plant Science
- Drug Discovery
- Complementary and alternative medicine