Isolation of resistomycin from a terrestrial actinomycete with trail resistance-overcoming activity

Xuefeidan Liu; Midori A. Arai; Kazufumi Toume; Masami Ishibashi

doi:10.1177/1934578x1801300119

Isolation of resistomycin from a terrestrial actinomycete with trail resistance-overcoming activity

Xuefeidan Liu, Midori A. Arai, Kazufumi Toume, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) potently induces apoptosis in most cancer cells, but not in normal cells, and, thus, has attracted intense interest as a promising antitumor agent. Activity-guided fractionation of the culture broth of the actinomycete CKK1172 strain led to the isolation of the antibiotic resistomycin (1) using human gastric adenocarcinoma AGS cells. Compound 1 exhibited TRAIL resistance-overcoming activity at 2 μM with 38% more inhibition than a treatment with 1 alone (without TRAIL) in TRAIL-resistant AGS cells.

Original language	English
Pages (from-to)	65-66
Number of pages	2
Journal	Natural product communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1177/1934578x1801300119
Publication status	Published - 2018 Jan
Externally published	Yes

Keywords

Actinomycete
Resistomycin
TRAIL resistance-overcoming activity

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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abstract = "Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) potently induces apoptosis in most cancer cells, but not in normal cells, and, thus, has attracted intense interest as a promising antitumor agent. Activity-guided fractionation of the culture broth of the actinomycete CKK1172 strain led to the isolation of the antibiotic resistomycin (1) using human gastric adenocarcinoma AGS cells. Compound 1 exhibited TRAIL resistance-overcoming activity at 2 μM with 38% more inhibition than a treatment with 1 alone (without TRAIL) in TRAIL-resistant AGS cells.",

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author = "Xuefeidan Liu and Arai, {Midori A.} and Kazufumi Toume and Masami Ishibashi",

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T1 - Isolation of resistomycin from a terrestrial actinomycete with trail resistance-overcoming activity

AU - Liu, Xuefeidan

AU - Arai, Midori A.

AU - Toume, Kazufumi

AU - Ishibashi, Masami

N1 - Funding Information: This study was supported by JSPS KAKENHI Grant Number 17H03992.

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Y1 - 2018/1

N2 - Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) potently induces apoptosis in most cancer cells, but not in normal cells, and, thus, has attracted intense interest as a promising antitumor agent. Activity-guided fractionation of the culture broth of the actinomycete CKK1172 strain led to the isolation of the antibiotic resistomycin (1) using human gastric adenocarcinoma AGS cells. Compound 1 exhibited TRAIL resistance-overcoming activity at 2 μM with 38% more inhibition than a treatment with 1 alone (without TRAIL) in TRAIL-resistant AGS cells.

AB - Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) potently induces apoptosis in most cancer cells, but not in normal cells, and, thus, has attracted intense interest as a promising antitumor agent. Activity-guided fractionation of the culture broth of the actinomycete CKK1172 strain led to the isolation of the antibiotic resistomycin (1) using human gastric adenocarcinoma AGS cells. Compound 1 exhibited TRAIL resistance-overcoming activity at 2 μM with 38% more inhibition than a treatment with 1 alone (without TRAIL) in TRAIL-resistant AGS cells.

KW - Actinomycete

KW - Resistomycin

KW - TRAIL resistance-overcoming activity

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Isolation of resistomycin from a terrestrial actinomycete with trail resistance-overcoming activity

Abstract

Keywords

ASJC Scopus subject areas

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