Isolation of resistomycin from a terrestrial actinomycete with trail resistance-overcoming activity

Xuefeidan Liu, Midori A. Arai, Kazufumi Toume, Masami Ishibashi

Research output: Contribution to journalArticle

Abstract

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) potently induces apoptosis in most cancer cells, but not in normal cells, and, thus, has attracted intense interest as a promising antitumor agent. Activity-guided fractionation of the culture broth of the actinomycete CKK1172 strain led to the isolation of the antibiotic resistomycin (1) using human gastric adenocarcinoma AGS cells. Compound 1 exhibited TRAIL resistance-overcoming activity at 2 μM with 38% more inhibition than a treatment with 1 alone (without TRAIL) in TRAIL-resistant AGS cells.

Original languageEnglish
Pages (from-to)65-66
Number of pages2
JournalNatural product communications
Volume13
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Keywords

  • Actinomycete
  • Resistomycin
  • TRAIL resistance-overcoming activity

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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