Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium

Research output: Contribution to journalArticle

Abstract

Izenamides A, B, and C (1-3), new linear depsipeptides, were isolated from a taxonomically distinct marine cyanobacterium. Izenamides A and B contain a statine moiety [(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid] and inhibited the activity of cathepsin D, an aspartic peptidase. Meanwhile, izenamides did not show growth-inhibitory activity against HeLa, HL60, or MCF-7 cells at up to 10 μM.

Original languageEnglish
Pages (from-to)1673-1681
Number of pages9
JournalJournal of Natural Products
Volume81
Issue number7
DOIs
Publication statusPublished - 2018 Jul 27

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Depsipeptides
Cyanobacteria
Cathepsin D
MCF-7 Cells
Peptide Hydrolases
Growth
statine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium. / Kanamori, Yuki; Iwasaki, Arihiro; Sumimoto, Shimpei; Matsubara, Teruhiko; Sato, Toshinori; Suenaga, Kiyotake.

In: Journal of Natural Products, Vol. 81, No. 7, 27.07.2018, p. 1673-1681.

Research output: Contribution to journalArticle

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