JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling

Bernhard Sporri, Panu E. Kovanen, Atsuo Sasaki, Akihiko Yoshimura, Warren J. Leonard

Research output: Contribution to journalArticle

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Abstract

JAB/suppressor of cytokine signaling 1 (SOCS1) STAT-induced STAT inhibitor-1 (SSI-1) (JAB/SOCS1/SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signaling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-γ, prolactin, growth hormone, and erythropoietin. The role of JAB/SOCS1/SSI-1 in IL-2 signaling has been analyzed. JAB/SOCS1/SSI-1 is strongly induced by IL-2 in peripheral blood T cells, and JAB/SOCS1/SSI-1 overexpression strongly inhibits IL-2-induced signal transducer and activator of transcription-5 (Stat5) phosphorylation and transcriptional activity. In cotransfection experiments, JAB/SOCS1/SSI-1 associates with both Jak1 and Jak3; however, JAB/SOCS1/SSI-1 had a greater effect on Jak1 tyrosine phosphorylation and kinase activity. JAB/SOCS1/SSI-1 also interacts with IL-2Rβ, and this interaction requires the A region (residues 313-382) of IL-2Rβ. However, this interaction was not essential for the inhibitory action of JAB. Thus, JAB/SOCS1/SSI-1 is an IL-2-induced inhibitor of IL-2 signaling that functions by inhibiting Jak kinase activity. This suggests an important role for JAB/SOCS1/SSI-1 in regulating T-cell responses.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalBlood
Volume97
Issue number1
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

Fingerprint

Interleukin-2
Cytokines
Phosphorylation
T-cells
Janus Kinase 1
interleukin 2 inhibitor
STAT5 Transcription Factor
Phosphotransferases
T-Lymphocytes
src Homology Domains
Erythropoietin
Interleukin-4
Prolactin
Protein-Tyrosine Kinases
Interferons
Growth Hormone
Interleukin-6
Blood Cells
Tyrosine
Blood

ASJC Scopus subject areas

  • Hematology

Cite this

JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. / Sporri, Bernhard; Kovanen, Panu E.; Sasaki, Atsuo; Yoshimura, Akihiko; Leonard, Warren J.

In: Blood, Vol. 97, No. 1, 01.01.2001, p. 221-226.

Research output: Contribution to journalArticle

Sporri, B, Kovanen, PE, Sasaki, A, Yoshimura, A & Leonard, WJ 2001, 'JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling', Blood, vol. 97, no. 1, pp. 221-226. https://doi.org/10.1182/blood.V97.1.221
Sporri, Bernhard ; Kovanen, Panu E. ; Sasaki, Atsuo ; Yoshimura, Akihiko ; Leonard, Warren J. / JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. In: Blood. 2001 ; Vol. 97, No. 1. pp. 221-226.
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