Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium lyngbya sp.

Arihiro Iwasaki; Osamu Ohno; Shinpei Sumimoto; Hidetoshi Ogawa; Kim Anh Nguyen; Kiyotake Suenaga

doi:10.1021/ol5036722

Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium lyngbya sp.

Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Hidetoshi Ogawa, Kim Anh Nguyen, Kiyotake Suenaga

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

An acetylene-containing lipopeptide, jahanyne, was isolated from the marine cyanobacterium Lyngbya sp. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral HPLC analyses, spectroscopic analyses, and derivatization reactions. Jahanyne significantly inhibited the growth of human cancer cells and induced apoptosis in HeLa cells.

Original language	English
Pages (from-to)	652-655
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	3
DOIs	https://doi.org/10.1021/ol5036722
Publication status	Published - 2015 Feb 6

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/ol5036722

Cite this

@article{b8c7bccead1c4bd793036920836cb2f6,

title = "Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium lyngbya sp.",

abstract = "An acetylene-containing lipopeptide, jahanyne, was isolated from the marine cyanobacterium Lyngbya sp. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral HPLC analyses, spectroscopic analyses, and derivatization reactions. Jahanyne significantly inhibited the growth of human cancer cells and induced apoptosis in HeLa cells.",

author = "Arihiro Iwasaki and Osamu Ohno and Shinpei Sumimoto and Hidetoshi Ogawa and Nguyen, {Kim Anh} and Kiyotake Suenaga",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = feb,

day = "6",

doi = "10.1021/ol5036722",

language = "English",

volume = "17",

pages = "652--655",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "3",

}

TY - JOUR

T1 - Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium lyngbya sp.

AU - Iwasaki, Arihiro

AU - Ohno, Osamu

AU - Sumimoto, Shinpei

AU - Ogawa, Hidetoshi

AU - Nguyen, Kim Anh

AU - Suenaga, Kiyotake

PY - 2015/2/6

Y1 - 2015/2/6

N2 - An acetylene-containing lipopeptide, jahanyne, was isolated from the marine cyanobacterium Lyngbya sp. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral HPLC analyses, spectroscopic analyses, and derivatization reactions. Jahanyne significantly inhibited the growth of human cancer cells and induced apoptosis in HeLa cells.

AB - An acetylene-containing lipopeptide, jahanyne, was isolated from the marine cyanobacterium Lyngbya sp. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral HPLC analyses, spectroscopic analyses, and derivatization reactions. Jahanyne significantly inhibited the growth of human cancer cells and induced apoptosis in HeLa cells.

UR - http://www.scopus.com/inward/record.url?scp=84922652650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922652650&partnerID=8YFLogxK

U2 - 10.1021/ol5036722

DO - 10.1021/ol5036722

M3 - Article

C2 - 25582897

AN - SCOPUS:84922652650

SN - 1523-7060

VL - 17

SP - 652

EP - 655

JO - Organic Letters

JF - Organic Letters

IS - 3

ER -

Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium lyngbya sp.

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this