Jahanyne, an apoptosis-inducing lipopeptide from the marine cyanobacterium lyngbya sp.

Arihiro Iwasaki, Osamu Ohno, Shinpei Sumimoto, Hidetoshi Ogawa, Kim Anh Nguyen, Kiyotake Suenaga

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

An acetylene-containing lipopeptide, jahanyne, was isolated from the marine cyanobacterium Lyngbya sp. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral HPLC analyses, spectroscopic analyses, and derivatization reactions. Jahanyne significantly inhibited the growth of human cancer cells and induced apoptosis in HeLa cells.

Original languageEnglish
Pages (from-to)652-655
Number of pages4
JournalOrganic Letters
Volume17
Issue number3
DOIs
Publication statusPublished - 2015 Feb 6

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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