Janus hydrogel microbeads for glucose sensing with ph calibration

Maru Ando, Mio Tsuchiya, Shun Itai, Tomomi Murayama, Yuta Kurashina, Yun Jung Heo, Hiroaki Onoe

Research output: Contribution to journalArticlepeer-review

Abstract

We present fluorescent Janus hydrogel microbeads for continuous glucose sensing with pH calibration. The Janus hydrogel microbeads, that consist of fluorescent glucose and pH sensors, were fabricated with a UV-assisted centrifugal microfluidic device. The microbead can calibrate the pH values of its surroundings and enables accurate measurements of glucose within various pH condi-tions. As a proof of concept, we succeeded in obtaining the accurate value of glucose concentration in a body-fluid-like sample solution. We believe that our fluorescent microbeads, with pH calibration capability, could be applied to fully implantable sensors for continuous glucose monitoring.

Original languageEnglish
Article number4829
JournalSensors
Volume21
Issue number14
DOIs
Publication statusPublished - 2021 Jul 2

Keywords

  • Glucose monitoring
  • Glucose sensor
  • Hydrogel
  • Janus particle
  • PH calibration

ASJC Scopus subject areas

  • Analytical Chemistry
  • Information Systems
  • Atomic and Molecular Physics, and Optics
  • Biochemistry
  • Instrumentation
  • Electrical and Electronic Engineering

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