Japanese Lung Cancer Registry Study: First prospective enrollment of a large number of surgical and nonsurgical cases in 2002

Noriyoshi Sawabata, Hisao Asamura, Tomoyuki Goya, Masaki Mori, Yoichi Nakanishi, Kenji Eguchi, Yoshihiko Koshiishi, Meinoshin Okumura, Etsuo Miyaoka, Yoshitaka Fujii

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Abstract

Purpose: To investigate prognoses of lung cancer patients prospectively enrolled in the Japan Lung Cancer Registry Study. Methods: Patients newly diagnosed as having lung cancer exclusively in 2002 were enrolled. Follow-up surveys were performed twice, in 2004 and 2009, and the final follow-up data with prognoses were analyzed for 14,695 patients (79%). Clinical stages were defined according to the sixth edition of the International Union Against Cancer-tumor, node, metastasis classification (2002). Results: The mean age was 67.1 years (range, 18-89 years), and there were 10,194 men (69.3%) and 4315 women (29.7%). The most frequent histology was adenocarcinoma (n = 8325, 56.7%), followed by squamous cell carcinoma (n = 3778, 26%) and small cell carcinoma (n = 1345, 9.2%). The distribution of clinical stages was as follows: IA, 4245 cases (29.3%); IB, 2248 (14.5%); IIA, 208 (1.4%); IIB, 918 (6.3%); IIIA, 1700 (11.8%); IIIB, 2110 (16.3%); and IV, 3037 (21.0%). The 5-year survival rates were 44.3% for all patients, 46.8% for those with non-small cell lung cancer, and 14.7% for those with small cell lung cancer. According to the clinical stage of non-small cell lung cancer and small cell lung cancer, the 5-year survival rates were 79.4 and 52.7% for stage IA, 56.9 and 39.3% for IB, 49.0 and 31.7% for IIA, 42.3 and 29.9% for IIB, 30.9 and 17.2% for IIIA, 16.7 and 12.4% for IIIB, and 5.8 and 3.8% for IV, respectively. Conclusion: Analysis of a large cohort in the Japanese registry study found that stage-specific prognosis was within a range similar to other reports. The data presented should provide an important reference for future clinical trials in Japan.

Original languageEnglish
Pages (from-to)1369-1375
Number of pages7
JournalJournal of Thoracic Oncology
Volume5
Issue number9
DOIs
Publication statusPublished - 2010 Sep
Externally publishedYes

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Registries
Lung Neoplasms
Prospective Studies
Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
Japan
Survival Rate
Hospital Distribution Systems
Small Cell Carcinoma
Squamous Cell Carcinoma
Histology
Adenocarcinoma
Clinical Trials
Neoplasm Metastasis
Neoplasms

Keywords

  • Japan
  • Lung cancer
  • Registry

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Japanese Lung Cancer Registry Study : First prospective enrollment of a large number of surgical and nonsurgical cases in 2002. / Sawabata, Noriyoshi; Asamura, Hisao; Goya, Tomoyuki; Mori, Masaki; Nakanishi, Yoichi; Eguchi, Kenji; Koshiishi, Yoshihiko; Okumura, Meinoshin; Miyaoka, Etsuo; Fujii, Yoshitaka.

In: Journal of Thoracic Oncology, Vol. 5, No. 9, 09.2010, p. 1369-1375.

Research output: Contribution to journalArticle

Sawabata, N, Asamura, H, Goya, T, Mori, M, Nakanishi, Y, Eguchi, K, Koshiishi, Y, Okumura, M, Miyaoka, E & Fujii, Y 2010, 'Japanese Lung Cancer Registry Study: First prospective enrollment of a large number of surgical and nonsurgical cases in 2002', Journal of Thoracic Oncology, vol. 5, no. 9, pp. 1369-1375. https://doi.org/10.1097/JTO.0b013e3181e452b9
Sawabata, Noriyoshi ; Asamura, Hisao ; Goya, Tomoyuki ; Mori, Masaki ; Nakanishi, Yoichi ; Eguchi, Kenji ; Koshiishi, Yoshihiko ; Okumura, Meinoshin ; Miyaoka, Etsuo ; Fujii, Yoshitaka. / Japanese Lung Cancer Registry Study : First prospective enrollment of a large number of surgical and nonsurgical cases in 2002. In: Journal of Thoracic Oncology. 2010 ; Vol. 5, No. 9. pp. 1369-1375.
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abstract = "Purpose: To investigate prognoses of lung cancer patients prospectively enrolled in the Japan Lung Cancer Registry Study. Methods: Patients newly diagnosed as having lung cancer exclusively in 2002 were enrolled. Follow-up surveys were performed twice, in 2004 and 2009, and the final follow-up data with prognoses were analyzed for 14,695 patients (79{\%}). Clinical stages were defined according to the sixth edition of the International Union Against Cancer-tumor, node, metastasis classification (2002). Results: The mean age was 67.1 years (range, 18-89 years), and there were 10,194 men (69.3{\%}) and 4315 women (29.7{\%}). The most frequent histology was adenocarcinoma (n = 8325, 56.7{\%}), followed by squamous cell carcinoma (n = 3778, 26{\%}) and small cell carcinoma (n = 1345, 9.2{\%}). The distribution of clinical stages was as follows: IA, 4245 cases (29.3{\%}); IB, 2248 (14.5{\%}); IIA, 208 (1.4{\%}); IIB, 918 (6.3{\%}); IIIA, 1700 (11.8{\%}); IIIB, 2110 (16.3{\%}); and IV, 3037 (21.0{\%}). The 5-year survival rates were 44.3{\%} for all patients, 46.8{\%} for those with non-small cell lung cancer, and 14.7{\%} for those with small cell lung cancer. According to the clinical stage of non-small cell lung cancer and small cell lung cancer, the 5-year survival rates were 79.4 and 52.7{\%} for stage IA, 56.9 and 39.3{\%} for IB, 49.0 and 31.7{\%} for IIA, 42.3 and 29.9{\%} for IIB, 30.9 and 17.2{\%} for IIIA, 16.7 and 12.4{\%} for IIIB, and 5.8 and 3.8{\%} for IV, respectively. Conclusion: Analysis of a large cohort in the Japanese registry study found that stage-specific prognosis was within a range similar to other reports. The data presented should provide an important reference for future clinical trials in Japan.",
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T2 - First prospective enrollment of a large number of surgical and nonsurgical cases in 2002

AU - Sawabata, Noriyoshi

AU - Asamura, Hisao

AU - Goya, Tomoyuki

AU - Mori, Masaki

AU - Nakanishi, Yoichi

AU - Eguchi, Kenji

AU - Koshiishi, Yoshihiko

AU - Okumura, Meinoshin

AU - Miyaoka, Etsuo

AU - Fujii, Yoshitaka

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N2 - Purpose: To investigate prognoses of lung cancer patients prospectively enrolled in the Japan Lung Cancer Registry Study. Methods: Patients newly diagnosed as having lung cancer exclusively in 2002 were enrolled. Follow-up surveys were performed twice, in 2004 and 2009, and the final follow-up data with prognoses were analyzed for 14,695 patients (79%). Clinical stages were defined according to the sixth edition of the International Union Against Cancer-tumor, node, metastasis classification (2002). Results: The mean age was 67.1 years (range, 18-89 years), and there were 10,194 men (69.3%) and 4315 women (29.7%). The most frequent histology was adenocarcinoma (n = 8325, 56.7%), followed by squamous cell carcinoma (n = 3778, 26%) and small cell carcinoma (n = 1345, 9.2%). The distribution of clinical stages was as follows: IA, 4245 cases (29.3%); IB, 2248 (14.5%); IIA, 208 (1.4%); IIB, 918 (6.3%); IIIA, 1700 (11.8%); IIIB, 2110 (16.3%); and IV, 3037 (21.0%). The 5-year survival rates were 44.3% for all patients, 46.8% for those with non-small cell lung cancer, and 14.7% for those with small cell lung cancer. According to the clinical stage of non-small cell lung cancer and small cell lung cancer, the 5-year survival rates were 79.4 and 52.7% for stage IA, 56.9 and 39.3% for IB, 49.0 and 31.7% for IIA, 42.3 and 29.9% for IIB, 30.9 and 17.2% for IIIA, 16.7 and 12.4% for IIIB, and 5.8 and 3.8% for IV, respectively. Conclusion: Analysis of a large cohort in the Japanese registry study found that stage-specific prognosis was within a range similar to other reports. The data presented should provide an important reference for future clinical trials in Japan.

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