JC virus agnoprotein colocalizes with tubulin

Shuichi Endo; Yuki Okada; Yasuko Orba; Hiroshi Nishihara; Shinya Tanaka; Kazuo Nagashima; Hirofumi Sawa

doi:10.1080/13550280390195333

JC virus agnoprotein colocalizes with tubulin

Shuichi Endo, Yuki Okada, Yasuko Orba, Hiroshi Nishihara, Shinya Tanaka, Kazuo Nagashima, Hirofumi Sawa

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.

Original language	English
Pages (from-to)	10-14
Number of pages	5
Journal	Journal of NeuroVirology
Volume	9
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1080/13550280390195333
Publication status	Published - 2003 Jan 1
Externally published	Yes

Keywords

Agnoprotein
JC virus
Tubulin

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

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Endo, S., Okada, Y., Orba, Y., Nishihara, H., Tanaka, S., Nagashima, K., & Sawa, H. (2003). JC virus agnoprotein colocalizes with tubulin. Journal of NeuroVirology, 9(SUPPL. 1), 10-14. https://doi.org/10.1080/13550280390195333

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title = "JC virus agnoprotein colocalizes with tubulin",

abstract = "The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.",

keywords = "Agnoprotein, JC virus, Tubulin",

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AU - Endo, Shuichi

AU - Okada, Yuki

AU - Orba, Yasuko

AU - Nishihara, Hiroshi

AU - Tanaka, Shinya

AU - Nagashima, Kazuo

AU - Sawa, Hirofumi

PY - 2003/1/1

Y1 - 2003/1/1

N2 - The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.

AB - The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.

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