Abstract
The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.
| Original language | English |
|---|---|
| Pages (from-to) | 10-14 |
| Number of pages | 5 |
| Journal | Journal of NeuroVirology |
| Volume | 9 |
| Issue number | SUPPL. 1 |
| Publication status | Published - 2003 Jun 13 |
| Externally published | Yes |
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Keywords
- Agnoprotein
- JC virus
- Tubulin
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Virology
Cite this
JC virus agnoprotein colocalizes with tubulin. / Endo, Shuichi; Okada, Yuki; Orba, Yasuko; Nishihara, Hiroshi; Tanaka, Shinya; Nagashima, Kazuo; Sawa, Hirofumi.
In: Journal of NeuroVirology, Vol. 9, No. SUPPL. 1, 13.06.2003, p. 10-14.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - JC virus agnoprotein colocalizes with tubulin
AU - Endo, Shuichi
AU - Okada, Yuki
AU - Orba, Yasuko
AU - Nishihara, Hiroshi
AU - Tanaka, Shinya
AU - Nagashima, Kazuo
AU - Sawa, Hirofumi
PY - 2003/6/13
Y1 - 2003/6/13
N2 - The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.
AB - The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.
KW - Agnoprotein
KW - JC virus
KW - Tubulin
UR - http://www.scopus.com/inward/record.url?scp=0038136789&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038136789&partnerID=8YFLogxK
M3 - Article
VL - 9
SP - 10
EP - 14
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
IS - SUPPL. 1
ER -