JC virus agnoprotein colocalizes with tubulin

Shuichi Endo, Yuki Okada, Yasuko Orba, Hiroshi Nishihara, Shinya Tanaka, Kazuo Nagashima, Hirofumi Sawa

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalJournal of NeuroVirology
Volume9
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2003 Jan 1
Externally publishedYes

Keywords

  • Agnoprotein
  • JC virus
  • Tubulin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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  • Cite this

    Endo, S., Okada, Y., Orba, Y., Nishihara, H., Tanaka, S., Nagashima, K., & Sawa, H. (2003). JC virus agnoprotein colocalizes with tubulin. Journal of NeuroVirology, 9(SUPPL. 1), 10-14. https://doi.org/10.1080/13550280390195333