TY - JOUR
T1 - JC virus agnoprotein colocalizes with tubulin
AU - Endo, Shuichi
AU - Okada, Yuki
AU - Orba, Yasuko
AU - Nishihara, Hiroshi
AU - Tanaka, Shinya
AU - Nagashima, Kazuo
AU - Sawa, Hirofumi
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2003
Y1 - 2003
N2 - The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.
AB - The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.
KW - Agnoprotein
KW - JC virus
KW - Tubulin
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U2 - 10.1080/13550280390195333
DO - 10.1080/13550280390195333
M3 - Article
C2 - 12709865
AN - SCOPUS:0038136789
VL - 9
SP - 10
EP - 14
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
IS - SUPPL. 1
ER -