Joint diseases and matrix metalloproteinases: A role for MMP-13

Hironari Takaishi, Tokuhiro Kimura, Seema Dalal, Yasunori Okada, Jeanine D'Armiento

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

The role of matrix metalloproteinases in disease has been investigated over the last two decades. A focus on this family proteases is particularly emphasized in two major arthritides in humans, osteoarthritis and rheumatoid arthritis. Early work described the presence of multiple MMP family members in the joint of the disease state and recent advances in the development of new knockout mice and disease models have allowed investigators to directly test the role of the MMP proteases in arthritis. MMP-13 is expressed by chondrocytes and synovial cells in human OA and RA and is thought to play a critical role in cartilage destruction. The recent development of an MMP-13 knockout mouse has documented the important role for this enzyme in cartilage formation and further studies under disease conditions promise to reveal the function of this enzyme in disease pathology. This review describes a body of research that supports the development of novel selective MMP-13 inhibitors with the hope of developing these compounds in clinical trials for the treatment of arthritis.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalCurrent Pharmaceutical Biotechnology
Volume9
Issue number1
DOIs
Publication statusPublished - 2008 Feb

Fingerprint

Joint Diseases
Matrix Metalloproteinases
Arthritis
Knockout Mice
Cartilage
Peptide Hydrolases
Matrix Metalloproteinase Inhibitors
Enzymes
Chondrocytes
Osteoarthritis
Rheumatoid Arthritis
Research Personnel
Clinical Trials
Pathology
Research

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Molecular Medicine
  • Biotechnology

Cite this

Joint diseases and matrix metalloproteinases : A role for MMP-13. / Takaishi, Hironari; Kimura, Tokuhiro; Dalal, Seema; Okada, Yasunori; D'Armiento, Jeanine.

In: Current Pharmaceutical Biotechnology, Vol. 9, No. 1, 02.2008, p. 47-54.

Research output: Contribution to journalArticle

Takaishi, H, Kimura, T, Dalal, S, Okada, Y & D'Armiento, J 2008, 'Joint diseases and matrix metalloproteinases: A role for MMP-13', Current Pharmaceutical Biotechnology, vol. 9, no. 1, pp. 47-54. https://doi.org/10.2174/138920108783497659
Takaishi, Hironari ; Kimura, Tokuhiro ; Dalal, Seema ; Okada, Yasunori ; D'Armiento, Jeanine. / Joint diseases and matrix metalloproteinases : A role for MMP-13. In: Current Pharmaceutical Biotechnology. 2008 ; Vol. 9, No. 1. pp. 47-54.
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