K-ras gene mutations in early colorectal cancer . . . flat elevated vs polyp-forming cancer . . .

H. Hasegawa, M. Ueda, M. Watanabe, T. Teramoto, M. Mukai, M. Kitajima

Research output: Contribution to journalArticle

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Abstract

K-ras gene mutations in early colorectal cancer were detected by two-step sensitive polymerase chain reaction (PCR) and enzyme digestion method. Early colorectal cancer was classified into flat elevated cancer or polypforming cancer according to morphology and presence of adenomatous components. A total of 60 paraffin-embedded tissue specimens from patients with early colorectal cancer were analysed. K-ras codon 12 mutations were detected in 23.3% (7/30) of flat elevated cancer and 63.3% (19/30) of polyp-forming cancer. The incidence of K-ras codon 12 mutations in flat elevated cancer was significantly lower than in polyp-forming cancer (P < 0.01). These data suggested that K-ras gene mutations may be correlated with morphology or clinical features in flat elevated cancer, and that flat elevated cancer may originate from a pathway different from adenoma-carcinoma sequence.

Original languageEnglish
Pages (from-to)1413-1416
Number of pages4
JournalOncogene
Volume10
Issue number7
Publication statusPublished - 1995 Apr 6

Fingerprint

ras Genes
Polyps
Colorectal Neoplasms
Mutation
Neoplasms
Codon
Adenoma
Paraffin
Digestion
Carcinoma
Polymerase Chain Reaction
Incidence
Enzymes

Keywords

  • Early colorectal cancer
  • Flat elevated
  • K-ras
  • Polyp-forming adenoma-carcinoma sequence

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Hasegawa, H., Ueda, M., Watanabe, M., Teramoto, T., Mukai, M., & Kitajima, M. (1995). K-ras gene mutations in early colorectal cancer . . . flat elevated vs polyp-forming cancer . . . Oncogene, 10(7), 1413-1416.

K-ras gene mutations in early colorectal cancer . . . flat elevated vs polyp-forming cancer . . . / Hasegawa, H.; Ueda, M.; Watanabe, M.; Teramoto, T.; Mukai, M.; Kitajima, M.

In: Oncogene, Vol. 10, No. 7, 06.04.1995, p. 1413-1416.

Research output: Contribution to journalArticle

Hasegawa, H, Ueda, M, Watanabe, M, Teramoto, T, Mukai, M & Kitajima, M 1995, 'K-ras gene mutations in early colorectal cancer . . . flat elevated vs polyp-forming cancer . . .', Oncogene, vol. 10, no. 7, pp. 1413-1416.
Hasegawa H, Ueda M, Watanabe M, Teramoto T, Mukai M, Kitajima M. K-ras gene mutations in early colorectal cancer . . . flat elevated vs polyp-forming cancer . . . Oncogene. 1995 Apr 6;10(7):1413-1416.
Hasegawa, H. ; Ueda, M. ; Watanabe, M. ; Teramoto, T. ; Mukai, M. ; Kitajima, M. / K-ras gene mutations in early colorectal cancer . . . flat elevated vs polyp-forming cancer . . . In: Oncogene. 1995 ; Vol. 10, No. 7. pp. 1413-1416.
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