K-sam-related Gene, N-sam, Encodes Fibroblast Growth Factor Receptor and Is Expressed in T-Lymphocytic Tumors

Yutaka Hattori, Hiroki Odagiri, Osamu Katoh, Hiromi Sakamoto, Toshirou Morita, Kunitada Shimotohno, Kensei Tobinai, Takashi Sugimura, Masaaki Terada

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We recently reported the isolation of the K-sam complementary DNA (cDNA), which was amplified preferentially in poorly differentiated types of stomach cancer and codes for one of the heparin-binding growth factor or fibroblast growth factor (FGF) receptor families. The K-sam-related gene, N-sam (NCC-IT-cell-derived sam), was isolated by screening of the cDNA libraries of human immature teratoma cells, NCC-IT. Sequence analysis of the N-sam cDNAs showed that N-sam encodes a human FGF receptor, the FLG protein. N-sam was expressed in lymphocytic leukemia/lymphoma cells, predominantly in the thymic T-cell phenotype. In a T-cell leukemia line, MOLT3, N-sam mRNA expression was markedly enhanced by 12-0-tetradecanoylphorbol-13-acetate treatment and was also up-regulated by basic FGF exposure. These results indicate that N-sam expression is regulated during T-cell ontogeny and modulated by its putative ligand exposure. The results also suggested that interaction between immature T-cell and marrow or thymic interstitial cells might be mediated by N-sam and basic FGF stored in the extracellular matrix of stromal cells.

Original languageEnglish
Pages (from-to)3367-3371
Number of pages5
JournalCancer Research
Volume52
Issue number12
Publication statusPublished - 1992 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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