Katorazone, a new yellow pigment with a 2-azaquinone-phenylhydrazone structure produced by Streptomyces sp. IFM 11299

Mohamed S. Abdelfattah, Kazufumi Toume, Midori A. Arai, Hyuma Masu, Masami Ishibashi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An unusual alkaloid with a 2-azaquinone-phenylhydrazone structure, katorazone (1), and other metabolites were isolated from the ethyl acetate extract of Streptomyces sp. IFM 11299. The chemical structure of katorazone (1) was elucidated by 1D and 2D NMR analyses together with HR-ESI mass spectrometry. Katorazone (1) showed a synergistic effect in combination with TRAIL and decreased the viability of human gastric adenocarcinoma (AGS) cells.

Original languageEnglish
Pages (from-to)3346-3348
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number26
DOIs
Publication statusPublished - 2012 Jun 27
Externally publishedYes

Keywords

  • Azaquinone
  • Phenylhydrazone
  • Streptomyces

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Katorazone, a new yellow pigment with a 2-azaquinone-phenylhydrazone structure produced by Streptomyces sp. IFM 11299'. Together they form a unique fingerprint.

  • Cite this