Keeping DCs awake by putting SOCS1 to sleep

Takashi Kobayashi, Akihiko Yoshimura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

It has recently been shown that small interfering RNA (siRNA)-mediated inhibition of suppressors of cytokine signalling 1 (SOCS1) function enhances the immunostimulatory capacity of dendritic cells (DCs), which leads to more effective cancer vaccination. This recent study demonstrates the importance of negative regulation of DC maturation and functions for DC-based immunotherapy.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalTrends in Immunology
Volume26
Issue number4
DOIs
Publication statusPublished - 2005 Apr
Externally publishedYes

Fingerprint

Dendritic Cells
Sleep
Cytokines
Immunotherapy
Small Interfering RNA
Vaccination
Neoplasms
Inhibition (Psychology)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Keeping DCs awake by putting SOCS1 to sleep. / Kobayashi, Takashi; Yoshimura, Akihiko.

In: Trends in Immunology, Vol. 26, No. 4, 04.2005, p. 177-179.

Research output: Contribution to journalArticle

Kobayashi, Takashi ; Yoshimura, Akihiko. / Keeping DCs awake by putting SOCS1 to sleep. In: Trends in Immunology. 2005 ; Vol. 26, No. 4. pp. 177-179.
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