Keeping DCs awake by putting SOCS1 to sleep

Takashi Kobayashi, Akihiko Yoshimura

Research output: Contribution to journalShort survey

25 Citations (Scopus)


It has recently been shown that small interfering RNA (siRNA)-mediated inhibition of suppressors of cytokine signalling 1 (SOCS1) function enhances the immunostimulatory capacity of dendritic cells (DCs), which leads to more effective cancer vaccination. This recent study demonstrates the importance of negative regulation of DC maturation and functions for DC-based immunotherapy.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalTrends in Immunology
Issue number4
Publication statusPublished - 2005 Apr

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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