@article{598d2a7044e6453881641c38dd50a7d4,
title = "Kinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes",
abstract = "Biological Sciences; Mathematical Biosciences; Systems Biology; Proteomics; Metabolomics; Metabolic Flux Analyisis; Omics",
keywords = "Biological Sciences, Mathematical Biosciences, Metabolic Flux Analyisis, Metabolomics, Omics, Proteomics, Systems Biology",
author = "Satoshi Ohno and Quek, {Lake Ee} and Krycer, {James R.} and Katsuyuki Yugi and Akiyoshi Hirayama and Satsuki Ikeda and Futaba Shoji and Kumi Suzuki and Tomoyoshi Soga and James, {David E.} and Shinya Kuroda",
note = "Funding Information: We are grateful to Dr. Shinsuke Uda, Dr. Hiroyuki Kubota, Dr. Fumio Matsuda, Dr. Hiroshi Shimizu, Dr. Yoshihiro Toya, and our laboratory members for fruitful discussion. We thank Nancy R. Gough, BioSerendipity, LLC, for writing and editorial assistance. The computational analysis of this work was performed in part with support of the super computer system of National Institute of Genetics (NIG), Research Organization of Information and Systems (ROIS). This research was facilitated by access to Sydney Mass Spectrometry, a core research facility at the University of Sydney. This work was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST (JPMJCR12W3) from the Japan Science and Technology Agency (JST), and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number (17H06300, 17H06299, 18H03979). S.O. was funded by JSPS KAKENHI Grant Number JP17K14864. L.-E.Q. was funded by the Judith and David Coffey Fund, and Cancer Institute NSW. J.R.K. was funded by an NHMRC Early Career Fellowship (APP1072440), Australian Diabetes Society Skip Martin Early Career Fellowship, and Diabetes Australia Research grant. D.E.J. is an NHMRC Senior Principal Research Fellow (APP1019680). K.Y. was funded by JSPS KAKENHI Grant Number JP15H05582 and JP18H05431, and ??Creation of Innovative Technology for Medical Applications Based on the Global Analyses and Regulation of Disease-Related Metabolites,? PRESTO (JPMJPR1538) from JST. A.H. was funded by the Research on Development of New Drugs (GAPFREE) from the Japan Agency for Medical Research and Development, AMED. T.S. was funded by the AMED-CREST from AMED. A.H. and T.S. were funded from Yamagata prefectural government and the City of Tsuruoka. S.O. D.E.J. and S.K. conceived the project. S.O. performed the modeling. L.-E.Q. J.R.K. A.H. S.I. F.S. K.S. and T.S. performed experiments. S.O. L.-E.Q. K.Y. and J.R.K. analyzed the data. S.O. and S.K. wrote the manuscript. All authors read and approved the final manuscript. The authors declare no competing interests. Funding Information: This work was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST ( JPMJCR12W3 ) from the Japan Science and Technology Agency (JST), and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number ( 17H06300 , 17H06299 , 18H03979 ). S.O. was funded by JSPS KAKENHI Grant Number JP17K14864 . L.-E.Q. was funded by the Judith and David Coffey Fund, and Cancer Institute NSW . J.R.K. was funded by an NHMRC Early Career Fellowship ( APP1072440 ), Australian Diabetes Society Skip Martin Early Career Fellowship, and Diabetes Australia Research grant. D.E.J. is an NHMRC Senior Principal Research Fellow ( APP1019680 ). K.Y. was funded by JSPS KAKENHI Grant Number JP15H05582 and JP18H05431 , and {\textquoteleft}{\textquoteleft}Creation of Innovative Technology for Medical Applications Based on the Global Analyses and Regulation of Disease-Related Metabolites,” PRESTO ( JPMJPR1538 ) from JST. A.H. was funded by the Research on Development of New Drugs (GAPFREE) from the Japan Agency for Medical Research and Development , AMED. T.S. was funded by the AMED-CREST from AMED . A.H. and T.S. were funded from Yamagata prefectural government and the City of Tsuruoka. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = sep,
day = "25",
doi = "10.1016/j.isci.2020.101479",
language = "English",
volume = "23",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "9",
}